| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 10.04 |
| RB | Jordan Howard RB | 14.20 |
| RB | Carlos Hyde RB | 18.00 |
| WR | Odell Beckham WR | 26.35 |
| WR | Kelvin Benjamin WR | 12.30 |
| TE | Travis Kelce TE | 14.10 |
| FLEX | David Johnson RB | 26.10 |
| FLEX | Willie Snead WR | 12.30 |
| DST | Philadelphia Eagles DST | -1.00 |
| Total | 132.39 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 32.50 |
| RB | Rashad Jennings RB | 6.90 |
| RB | Thomas Rawls RB | 3.80 |
| WR | Cole Beasley WR | 8.10 |
| WR | Antonio Brown WR | 29.60 |
| TE | Dennis Pitta TE | 4.90 |
| FLEX | Jordy Nelson WR | 13.10 |
| FLEX | Steve Smith WR | 4.00 |
| DST | Detroit Lions DST | 5.00 |
| Total | 107.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | Philip Rivers QB | 19.68 |
| BN | Devontae Booker RB | 10.60 |
| BN | Knile Davis RB | 0.60 |
| BN | Derrick Henry RB | 12.00 |
| BN | Theo Riddick RB | 8.30 |
| BN | Terrance West RB | 7.90 |
| BN | Tyler Lockett WR | 1.65 |
| BN | Jordan Matthews TE | 6.70 |
| BN | Donte Moncrief WR | 13.50 |
| BN | Cameron Brate TE | 6.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Tim Hightower RB | 17.50 |
| BN | Mark Ingram RB | 29.20 |
| BN | Wendell Smallwood RB | 5.20 |
| BN | James White RB | 4.20 |
| BN | Martavis Bryant WR | 0.00 |
| BN | Cameron Meredith WR | 2.90 |
| BN | DeVante Parker WR | 7.90 |
| BN | Coby Fleener TE | 7.90 |
| BN | Arizona Cardinals DST | 1.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 19.68 | 51% |
| RB | David Johnson RB | 26.10 | 73% |
| RB | Carlos Hyde RB | 18.00 | |
| WR | Odell Beckham WR | 26.35 | 97% |
| WR | Donte Moncrief WR | 13.50 | |
| TE | Travis Kelce TE | 14.10 | 100% |
| FLEX | Jordan Howard RB | 14.20 | 144.9% |
| FLEX | Kelvin Benjamin WR | 12.30 | |
| DST | Philadelphia Eagles DST | -1.00 | -- |
| Total | 143.23 | 92.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 32.50 | 100% |
| RB | Mark Ingram RB | 29.20 | 22.9% |
| RB | Tim Hightower RB | 17.50 | |
| WR | Antonio Brown WR | 29.60 | 88.3% |
| WR | Jordy Nelson WR | 13.10 | |
| TE | Coby Fleener TE | 7.90 | 62% |
| FLEX | Cole Beasley WR | 8.10 | 106.9% |
| FLEX | DeVante Parker WR | 7.90 | |
| DST | Detroit Lions DST | 5.00 | 100% |
| Total | 150.8 | 71.6% | |