| Starters | ||
| Pos | Player | Points |
| QB | Joe Flacco QB | -2.90 |
| RB | LeVeon Bell RB | 18.80 |
| RB | Devonta Freeman RB | 21.30 |
| WR | Ted Ginn Jr. WR | 13.50 |
| WR | Tyreek Hill WR | 18.00 |
| TE | Martellus Bennett TE | 2.70 |
| FLEX | Lamar Miller RB | 6.80 |
| FLEX | Kenny Stills WR | 7.10 |
| DST | New England Patriots DST | 3.00 |
| Total | 88.3 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 20.80 |
| RB | Mark Ingram RB | 9.60 |
| RB | LeSean McCoy RB | 10.40 |
| WR | Antonio Brown WR | 22.00 |
| WR | Martavis Bryant WR | 4.00 |
| TE | Delanie Walker TE | 5.10 |
| FLEX | Michael Crabtree WR | 1.20 |
| FLEX | Terrelle Pryor WR | 2.90 |
| DST | Green Bay Packers DST | 5.00 |
| Total | 81 | |
| Bench | ||
| Pos | Player | Points |
| BN | Andrew Luck QB | 0.00 |
| BN | Jamaal Charles RB | 12.20 |
| BN | Adam Thielen WR | 12.30 |
| BN | Dontrelle Inman WR | 0.70 |
| BN | Jeremy Kerley WR | 8.30 |
| BN | Austin Hooper TE | 1.40 |
| BN | Zach Miller TE | 2.20 |
| BN | Cincinnati Bengals DST | 14.00 |
| BN | Mack Hollins WR | 0.00 |
| BN | Jamaal Williams RB | 0.60 |
| Bench | ||
| Pos | Player | Points |
| BN | Joe Mixon RB | 11.60 |
| BN | Wendell Smallwood RB | 10.40 |
| BN | Jordy Nelson WR | 20.20 |
| BN | Robby Anderson WR | 17.00 |
| BN | Los Angeles Chargers DST | 5.00 |
| BN | James Conner RB | 0.00 |
| BN | Chris Carson RB | 12.20 |
| BN | Deshaun Watson QB | 20.10 |
| BN | Terrance Williams WR | 6.20 |
| BN | Coby Fleener TE | 2.60 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Andrew Luck QB | 0.00 | 0% |
| RB | Devonta Freeman RB | 21.30 | 100% |
| RB | LeVeon Bell RB | 18.80 | |
| WR | Tyreek Hill WR | 18.00 | 100% |
| WR | Ted Ginn Jr. WR | 13.50 | |
| TE | Martellus Bennett TE | 2.70 | 100% |
| FLEX | Adam Thielen WR | 12.30 | 56.7% |
| FLEX | Jamaal Charles RB | 12.20 | |
| DST | Cincinnati Bengals DST | 14.00 | 21.4% |
| Total | 112.8 | 78.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 20.80 | 100% |
| RB | Chris Carson RB | 12.20 | 84% |
| RB | Joe Mixon RB | 11.60 | |
| WR | Antonio Brown WR | 22.00 | 61.6% |
| WR | Jordy Nelson WR | 20.20 | |
| TE | Delanie Walker TE | 5.10 | 100% |
| FLEX | Robby Anderson WR | 17.00 | 15% |
| FLEX | LeSean McCoy RB | 10.40 | |
| DST | Green Bay Packers DST | 5.00 | 100% |
| Total | 124.3 | 65.2% | |