| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 16.50 |
| RB | C.J. Anderson RB | 5.30 |
| RB | Leonard Fournette RB | 15.50 |
| WR | DeAndre Hopkins WR | 11.10 |
| WR | DeVante Parker WR | 17.60 |
| TE | Rob Gronkowski TE | 18.90 |
| FLEX | Duke Johnson RB | 19.40 |
| FLEX | Devin Funchess TE | 7.80 |
| DST | Houston Texans DST | 9.00 |
| Total | 121.1 | |
| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 19.70 |
| RB | Chris Johnson RB | 2.60 |
| RB | Kerwynn Williams RB | 2.50 |
| WR | Kelvin Benjamin WR | 1.80 |
| WR | J.J. Nelson WR | 0.00 |
| TE | Evan Engram TE | 7.00 |
| FLEX | Tyrell Williams WR | 2.50 |
| FLEX | Chris Hogan WR | 20.80 |
| DST | Pittsburgh Steelers DST | 6.00 |
| Total | 62.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | Paul Perkins RB | 4.00 |
| BN | Darren Sproles RB | 1.10 |
| BN | Marqise Lee WR | 8.60 |
| BN | Randall Cobb WR | 0.00 |
| BN | Eric Decker WR | 6.90 |
| BN | Rashard Higgins WR | 2.00 |
| BN | Kenny Golladay WR | 3.50 |
| BN | Mike Williams WR | 0.00 |
| BN | Mike Tolbert RB | 4.10 |
| BN | Paul Richardson WR | 10.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Arizona Cardinals DST | 2.00 |
| BN | Pierre Garcon WR | 17.70 |
| BN | Dion Lewis RB | 5.40 |
| BN | Charcandrick West RB | 2.30 |
| BN | Latavius Murray RB | 0.50 |
| BN | Eddie Lacy RB | 0.00 |
| BN | Carson Palmer QB | 21.70 |
| BN | ArDarius Stewart WR | 2.90 |
| BN | Trevor Siemian QB | 7.60 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 16.50 | 100% |
| RB | Duke Johnson RB | 19.40 | 59.6% |
| RB | Leonard Fournette RB | 15.50 | |
| WR | DeVante Parker WR | 17.60 | 100% |
| WR | DeAndre Hopkins WR | 11.10 | |
| TE | Rob Gronkowski TE | 18.90 | 100% |
| FLEX | Paul Richardson WR | 10.00 | 146.2% |
| FLEX | Marqise Lee WR | 8.60 | |
| DST | Houston Texans DST | 9.00 | 100% |
| Total | 126.6 | 95.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Carson Palmer QB | 21.70 | 90.8% |
| RB | Dion Lewis RB | 5.40 | 63.8% |
| RB | Chris Johnson RB | 2.60 | |
| WR | Chris Hogan WR | 20.80 | 4.7% |
| WR | Pierre Garcon WR | 17.70 | |
| TE | Evan Engram TE | 7.00 | 100% |
| FLEX | ArDarius Stewart WR | 2.90 | 431.5% |
| FLEX | Tyrell Williams WR | 2.50 | |
| DST | Pittsburgh Steelers DST | 6.00 | 100% |
| Total | 86.6 | 72.6% | |