| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 18.88 |
| RB | Jordan Howard RB | 13.30 |
| RB | Carlos Hyde RB | 12.70 |
| WR | Odell Beckham WR | 20.50 |
| WR | Tyler Lockett WR | 6.55 |
| TE | Cameron Brate TE | 7.70 |
| FLEX | David Johnson RB | 32.60 |
| FLEX | Willie Snead WR | 3.10 |
| DST | Philadelphia Eagles DST | 9.00 |
| Total | 124.33 | |
| Starters | ||
| Pos | Player | Points |
| QB | Joe Flacco QB | 14.48 |
| RB | LeVeon Bell RB | 27.20 |
| RB | Devonta Freeman RB | 12.80 |
| WR | Doug Baldwin WR | 30.20 |
| WR | Ted Ginn Jr. WR | 5.00 |
| TE | Martellus Bennett TE | 8.90 |
| FLEX | Tyreek Hill WR | 17.40 |
| FLEX | Greg Olsen TE | 8.90 |
| DST | New England Patriots DST | 16.00 |
| Total | 140.88 | |
| Bench | ||
| Pos | Player | Points |
| BN | Russell Wilson QB | 33.60 |
| BN | Devontae Booker RB | 9.10 |
| BN | Knile Davis RB | 0.00 |
| BN | Derrick Henry RB | 4.50 |
| BN | Theo Riddick RB | 0.00 |
| BN | Terrance West RB | 7.00 |
| BN | Kelvin Benjamin WR | 14.30 |
| BN | Jordan Matthews TE | 2.20 |
| BN | Donte Moncrief WR | 10.00 |
| BN | Travis Kelce TE | 27.50 |
| Bench | ||
| Pos | Player | Points |
| BN | Carson Palmer QB | 15.26 |
| BN | Alex Smith QB | 22.36 |
| BN | Alfred Blue RB | 17.00 |
| BN | Lamar Miller RB | 0.00 |
| BN | Danny Amendola WR | 0.00 |
| BN | Brandon Marshall WR | 3.80 |
| BN | Eddie Royal WR | 0.00 |
| BN | Cincinnati Bengals DST | 11.00 |
| BN | Los Angeles Rams DST | 8.00 |
| BN | Houston Texans DST | 10.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 33.60 | 56.2% |
| RB | David Johnson RB | 32.60 | 56.6% |
| RB | Jordan Howard RB | 13.30 | |
| WR | Odell Beckham WR | 20.50 | 77.7% |
| WR | Kelvin Benjamin WR | 14.30 | |
| TE | Travis Kelce TE | 27.50 | 28% |
| FLEX | Carlos Hyde RB | 12.70 | 157.3% |
| FLEX | Donte Moncrief WR | 10.00 | |
| DST | Philadelphia Eagles DST | 9.00 | 100% |
| Total | 173.5 | 71.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Alex Smith QB | 22.36 | 64.8% |
| RB | LeVeon Bell RB | 27.20 | 90.5% |
| RB | Alfred Blue RB | 17.00 | |
| WR | Doug Baldwin WR | 30.20 | 73.9% |
| WR | Tyreek Hill WR | 17.40 | |
| TE | Greg Olsen TE | 8.90 | 100% |
| FLEX | Devonta Freeman RB | 12.80 | 121.2% |
| FLEX | Martellus Bennett TE | 8.90 | |
| DST | New England Patriots DST | 16.00 | 100% |
| Total | 160.76 | 87.6% | |