| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 11.90 |
| RB | Leonard Fournette RB | 15.40 |
| RB | Duke Johnson RB | 2.80 |
| WR | DeAndre Hopkins WR | 12.00 |
| WR | Devin Funchess WR | 14.00 |
| TE | Jimmy Graham TE | 10.10 |
| FLEX | Rob Gronkowski TE | 19.20 |
| FLEX | Julio Jones WR | 3.40 |
| DST | Chicago Bears DST | 10.00 |
| Total | 98.8 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 14.50 |
| RB | Mark Ingram RB | 21.20 |
| RB | Joe Mixon RB | 4.70 |
| WR | Antonio Brown WR | 20.10 |
| WR | Robby Anderson WR | 15.40 |
| TE | Delanie Walker TE | 14.80 |
| FLEX | Rex Burkhead RB | 24.70 |
| FLEX | Tevin Coleman RB | 6.40 |
| DST | Los Angeles Chargers DST | 12.00 |
| Total | 133.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | C.J. Anderson RB | 13.00 |
| BN | Mike Williams WR | 0.00 |
| BN | Marqise Lee WR | 18.10 |
| BN | Kenny Golladay WR | 5.40 |
| BN | Houston Texans DST | 4.00 |
| BN | Matt Ryan QB | 7.00 |
| BN | Chris Ivory RB | 2.00 |
| BN | Paul Richardson WR | 1.80 |
| BN | Patrick Mahomes QB | 0.00 |
| BN | Jeremy Maclin WR | 6.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Jordy Nelson WR | 4.20 |
| BN | Michael Crabtree WR | 0.00 |
| BN | Martavis Bryant WR | 7.90 |
| BN | James Conner RB | 1.20 |
| BN | Deshaun Watson QB | 0.00 |
| BN | Terrelle Pryor WR | 0.00 |
| BN | Matt Breida RB | 5.40 |
| BN | Tennessee Titans DST | 8.00 |
| BN | Damien Williams RB | 0.00 |
| BN | Will Fuller WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 11.90 | 100% |
| RB | Leonard Fournette RB | 15.40 | 64.1% |
| RB | C.J. Anderson RB | 13.00 | |
| WR | Marqise Lee WR | 18.10 | 86.4% |
| WR | DeAndre Hopkins WR | 12.00 | |
| TE | Rob Gronkowski TE | 19.20 | 52.6% |
| FLEX | Devin Funchess TE | 14.00 | 93.8% |
| FLEX | Jimmy Graham TE | 10.10 | |
| DST | Chicago Bears DST | 10.00 | 100% |
| Total | 123.7 | 79.9% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 14.50 | 100% |
| RB | Rex Burkhead RB | 24.70 | 56.4% |
| RB | Mark Ingram RB | 21.20 | |
| WR | Antonio Brown WR | 20.10 | 100% |
| WR | Robby Anderson WR | 15.40 | |
| TE | Delanie Walker TE | 14.80 | 100% |
| FLEX | Martavis Bryant WR | 7.90 | 217.5% |
| FLEX | Tevin Coleman RB | 6.40 | |
| DST | Los Angeles Chargers DST | 12.00 | 100% |
| Total | 137 | 97.7% | |