| Starters | ||
| Pos | Player | Points |
| QB | Blaine Gabbert QB | 10.00 |
| RB | Christian McCaffrey RB | 13.40 |
| RB | DeMarco Murray RB | 8.90 |
| WR | Brandin Cooks WR | 3.20 |
| WR | Marvin Jones WR | 11.00 |
| TE | Zach Ertz TE | 3.40 |
| FLEX | Emmanuel Sanders WR | 2.10 |
| FLEX | Davante Adams WR | 6.20 |
| DST | Tampa Bay Buccaneers DST | 6.00 |
| Total | 64.2 | |
| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 12.60 |
| RB | Samaje Perine RB | 8.40 |
| RB | Frank Gore RB | 6.10 |
| WR | Golden Tate WR | 10.90 |
| WR | Jarvis Landry WR | 8.50 |
| TE | Tyler Kroft TE | 4.00 |
| FLEX | Bilal Powell RB | 12.00 |
| FLEX | DeSean Jackson WR | 3.40 |
| DST | Kansas City Chiefs DST | -8.00 |
| Total | 57.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | Jay Ajayi RB | 6.10 |
| BN | Baltimore Ravens DST | 14.00 |
| BN | Aaron Jones RB | 8.00 |
| BN | Adam Shaheen TE | 0.00 |
| BN | Julian Edelman WR | 0.00 |
| BN | T.Y. Hilton WR | 12.60 |
| BN | C.J. Beathard QB | 0.00 |
| BN | DeShone Kizer QB | 13.20 |
| BN | Ryan Fitzpatrick QB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Ty Montgomery RB | 0.00 |
| BN | Taylor Gabriel WR | 1.60 |
| BN | Alex Smith QB | 37.60 |
| BN | Detroit Lions DST | -4.00 |
| BN | George Kittle TE | 3.00 |
| BN | DeVante Parker WR | 1.00 |
| BN | Chad Kelly QB | 0.00 |
| BN | Jeremy McNichols RB | 0.00 |
| BN | Tyler Boyd WR | 2.50 |
| BN | Jonathan Williams RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | DeShone Kizer QB | 13.20 | 75.8% |
| RB | Christian McCaffrey RB | 13.40 | 100% |
| RB | DeMarco Murray RB | 8.90 | |
| WR | T.Y. Hilton WR | 12.60 | 60.2% |
| WR | Marvin Jones WR | 11.00 | |
| TE | Zach Ertz TE | 3.40 | 100% |
| FLEX | Aaron Jones RB | 8.00 | 58.5% |
| FLEX | Davante Adams WR | 6.20 | |
| DST | Baltimore Ravens DST | 14.00 | 42.9% |
| Total | 90.7 | 70.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Alex Smith QB | 37.60 | 33.5% |
| RB | Bilal Powell RB | 12.00 | 71.1% |
| RB | Samaje Perine RB | 8.40 | |
| WR | Golden Tate WR | 10.90 | 100% |
| WR | Jarvis Landry WR | 8.50 | |
| TE | Tyler Kroft TE | 4.00 | 100% |
| FLEX | Frank Gore RB | 6.10 | 162.1% |
| FLEX | DeSean Jackson WR | 3.40 | |
| DST | Detroit Lions DST | -4.00 | -- |
| Total | 86.9 | 66.6% | |