| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 18.30 |
| RB | Jerick McKinnon RB | 13.70 |
| RB | Latavius Murray RB | 11.20 |
| WR | Randall Cobb WR | 0.00 |
| WR | Terrance Williams WR | 3.10 |
| TE | Evan Engram TE | 19.40 |
| FLEX | Dion Lewis RB | 9.20 |
| FLEX | Tyrell Williams WR | 1.30 |
| DST | Pittsburgh Steelers DST | 1.00 |
| Total | 77.2 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 17.60 |
| RB | Jordan Howard RB | 3.80 |
| RB | Carlos Hyde RB | 8.10 |
| WR | Tyler Lockett WR | 11.10 |
| WR | Jordan Matthews WR | 1.90 |
| TE | Travis Kelce TE | 23.40 |
| FLEX | Devontae Booker RB | 1.30 |
| FLEX | Derrick Henry RB | 16.90 |
| DST | Philadelphia Eagles DST | 2.00 |
| Total | 86.1 | |
| Bench | ||
| Pos | Player | Points |
| BN | Arizona Cardinals DST | 3.00 |
| BN | Kelvin Benjamin WR | 0.00 |
| BN | Pierre Garcon WR | 0.00 |
| BN | Charcandrick West RB | 0.00 |
| BN | Eddie Lacy RB | 0.30 |
| BN | Greg Olsen TE | 0.00 |
| BN | Ed Dickson TE | 2.80 |
| BN | Chris Hogan WR | 0.00 |
| BN | Josh McCown QB | 31.10 |
| BN | Kerwynn Williams RB | 9.70 |
| Bench | ||
| Pos | Player | Points |
| BN | David Johnson RB | 0.00 |
| BN | Theo Riddick RB | 14.70 |
| BN | Terrance West RB | 0.00 |
| BN | Odell Beckham WR | 0.00 |
| BN | Donte Moncrief WR | 6.20 |
| BN | Willie Snead WR | 4.10 |
| BN | Cameron Brate TE | 16.90 |
| BN | Ben Roethlisberger QB | 18.00 |
| BN | Los Angeles Rams DST | 22.00 |
| BN | Jay Cutler QB | 13.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh McCown QB | 31.10 | 58.8% |
| RB | Jerick McKinnon RB | 13.70 | 100% |
| RB | Latavius Murray RB | 11.20 | |
| WR | Terrance Williams WR | 3.10 | 70.5% |
| WR | Tyrell Williams WR | 1.30 | |
| TE | Evan Engram TE | 19.40 | 100% |
| FLEX | Kerwynn Williams RB | 9.70 | 55.6% |
| FLEX | Dion Lewis RB | 9.20 | |
| DST | Arizona Cardinals DST | 3.00 | 33.3% |
| Total | 101.7 | 75.9% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Ben Roethlisberger QB | 18.00 | 97.8% |
| RB | Derrick Henry RB | 16.90 | 37.7% |
| RB | Theo Riddick RB | 14.70 | |
| WR | Tyler Lockett WR | 11.10 | 75.1% |
| WR | Donte Moncrief WR | 6.20 | |
| TE | Travis Kelce TE | 23.40 | 100% |
| FLEX | Cameron Brate TE | 16.90 | 72.8% |
| FLEX | Carlos Hyde RB | 8.10 | |
| DST | Los Angeles Rams DST | 22.00 | 9.1% |
| Total | 137.3 | 62.7% | |