| Starters | ||
| Pos | Player | Points |
| QB | Blaine Gabbert QB | 8.30 |
| RB | DeMarco Murray RB | 5.70 |
| RB | Christian McCaffrey RB | 6.80 |
| WR | Brandin Cooks WR | 4.30 |
| WR | Marvin Jones WR | 7.90 |
| TE | Jason Witten TE | 8.50 |
| FLEX | T.Y. Hilton WR | 3.00 |
| FLEX | Davante Adams WR | 25.40 |
| DST | Green Bay Packers DST | 6.00 |
| Total | 75.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Alex Smith QB | 11.10 |
| RB | Frank Gore RB | 14.50 |
| RB | Samaje Perine RB | 7.20 |
| WR | Jarvis Landry WR | 21.10 |
| WR | Golden Tate WR | 18.50 |
| TE | Stephen Anderson TE | 2.60 |
| FLEX | Bilal Powell RB | 3.50 |
| FLEX | DeSean Jackson WR | 8.40 |
| DST | Cleveland Browns DST | 1.00 |
| Total | 87.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | Ryan Fitzpatrick QB | 0.00 |
| BN | Jay Ajayi RB | 8.50 |
| BN | Julian Edelman WR | 0.00 |
| BN | Emmanuel Sanders WR | 2.10 |
| BN | Zach Ertz TE | 0.00 |
| BN | Baltimore Ravens DST | -6.00 |
| BN | C.J. Beathard QB | 0.00 |
| BN | DeShone Kizer QB | 17.30 |
| BN | Aaron Jones RB | -0.20 |
| BN | Adam Shaheen TE | 12.40 |
| Bench | ||
| Pos | Player | Points |
| BN | DeVante Parker WR | 6.00 |
| BN | Detroit Lions DST | 10.00 |
| BN | Tyler Boyd WR | 2.00 |
| BN | Taylor Gabriel WR | 2.40 |
| BN | Kirk Cousins QB | 8.80 |
| BN | LeGarrette Blount RB | 3.30 |
| BN | Ty Montgomery RB | 0.00 |
| BN | Tyler Kroft TE | 0.00 |
| BN | George Kittle TE | 2.00 |
| BN | Jonathan Williams RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | DeShone Kizer QB | 17.30 | 48% |
| RB | Jay Ajayi RB | 8.50 | 81.7% |
| RB | Christian McCaffrey RB | 6.80 | |
| WR | Davante Adams WR | 25.40 | 36.6% |
| WR | Marvin Jones WR | 7.90 | |
| TE | Adam Shaheen TE | 12.40 | 68.5% |
| FLEX | Jason Witten TE | 8.50 | 200% |
| FLEX | DeMarco Murray RB | 5.70 | |
| DST | Green Bay Packers DST | 6.00 | 100% |
| Total | 98.5 | 77.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Alex Smith QB | 11.10 | 100% |
| RB | Frank Gore RB | 14.50 | 100% |
| RB | Samaje Perine RB | 7.20 | |
| WR | Jarvis Landry WR | 21.10 | 100% |
| WR | Golden Tate WR | 18.50 | |
| TE | Stephen Anderson TE | 2.60 | 100% |
| FLEX | DeSean Jackson WR | 8.40 | 82.6% |
| FLEX | DeVante Parker WR | 6.00 | |
| DST | Detroit Lions DST | 10.00 | 10% |
| Total | 99.4 | 88.4% | |