| Starters | ||
| Pos | Player | Points |
| QB | Jameis Winston QB | 14.40 |
| RB | Mike Davis RB | 7.00 |
| RB | Marshawn Lynch RB | 12.90 |
| WR | Josh Gordon WR | 14.40 |
| WR | Michael Thomas WR | 22.70 |
| TE | Austin Seferian-Jenkins TE | 0.60 |
| FLEX | Jamison Crowder WR | 5.50 |
| FLEX | Alshon Jeffery WR | 13.70 |
| DST | Denver Broncos DST | 16.00 |
| Total | 107.2 | |
| Starters | ||
| Pos | Player | Points |
| QB | Carson Wentz QB | 27.20 |
| RB | Isaiah Crowell RB | 14.60 |
| RB | Matt Forte RB | 4.40 |
| WR | Mike Evans WR | 3.50 |
| WR | Demaryius Thomas WR | 19.30 |
| TE | O.J. Howard TE | 11.40 |
| FLEX | Mohamed Sanu WR | 17.30 |
| FLEX | Doug Martin RB | 10.00 |
| DST | Seattle Seahawks DST | -2.00 |
| Total | 105.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | Peyton Barber RB | 6.80 |
| BN | Ameer Abdullah RB | 0.00 |
| BN | Andy Dalton QB | 7.60 |
| BN | Danny Woodhead RB | 5.60 |
| BN | Jimmy Garoppolo QB | 15.10 |
| BN | Marcedes Lewis TE | 0.00 |
| BN | Marlon Mack RB | 5.40 |
| BN | Corey Davis WR | 4.40 |
| BN | Trent Taylor WR | 2.90 |
| BN | Zay Jones WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Quincy Enunwa WR | 0.00 |
| BN | Derek Carr QB | 10.40 |
| BN | Rob Kelley RB | 0.00 |
| BN | Jonathan Stewart RB | 28.30 |
| BN | DeAndre Washington RB | 2.40 |
| BN | Corey Coleman WR | 14.70 |
| BN | Allen Hurns WR | 0.00 |
| BN | Eric Decker WR | 7.10 |
| BN | David Njoku TE | 0.80 |
| BN | John Ross WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 15.10 | 95.4% |
| RB | Marshawn Lynch RB | 12.90 | 100% |
| RB | Mike Davis RB | 7.00 | |
| WR | Michael Thomas WR | 22.70 | 100% |
| WR | Josh Gordon WR | 14.40 | |
| TE | Austin Seferian-Jenkins TE | 0.60 | 100% |
| FLEX | Alshon Jeffery WR | 13.70 | 93.7% |
| FLEX | Peyton Barber RB | 6.80 | |
| DST | Denver Broncos DST | 16.00 | 100% |
| Total | 109.2 | 98.2% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Carson Wentz QB | 27.20 | 100% |
| RB | Jonathan Stewart RB | 28.30 | 44.3% |
| RB | Isaiah Crowell RB | 14.60 | |
| WR | Demaryius Thomas WR | 19.30 | 62.3% |
| WR | Mohamed Sanu WR | 17.30 | |
| TE | O.J. Howard TE | 11.40 | 100% |
| FLEX | Corey Coleman WR | 14.70 | 110.5% |
| FLEX | Doug Martin RB | 10.00 | |
| DST | Seattle Seahawks DST | -2.00 | -- |
| Total | 140.8 | 75.1% | |