| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 26.80 |
| RB | Marshawn Lynch RB | 3.10 |
| RB | Frank Gore RB | 12.20 |
| WR | Julio Jones WR | 12.60 |
| WR | Golden Tate WR | 15.80 |
| TE | Jimmy Graham TE | 10.70 |
| FLEX | Ty Montgomery RB | 9.00 |
| FLEX | Jarvis Landry WR | 7.80 |
| DST | Kansas City Chiefs DST | 11.00 |
| Total | 109 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 3.50 |
| RB | Carlos Hyde RB | 22.90 |
| RB | Jordan Howard RB | 29.10 |
| WR | Odell Beckham WR | 24.40 |
| WR | Tyler Lockett WR | 5.60 |
| TE | Travis Kelce TE | 0.60 |
| FLEX | Theo Riddick RB | 5.80 |
| FLEX | Jordan Matthews TE | 7.60 |
| DST | Los Angeles Rams DST | 2.00 |
| Total | 101.5 | |
| Bench | ||
| Pos | Player | Points |
| BN | Samaje Perine RB | 4.00 |
| BN | Bilal Powell RB | 9.70 |
| BN | LeGarrette Blount RB | 12.70 |
| BN | Brandon Marshall WR | 10.60 |
| BN | Breshad Perriman WR | 0.00 |
| BN | Taylor Gabriel WR | 16.40 |
| BN | DeSean Jackson WR | 16.40 |
| BN | Kenny Britt WR | 12.90 |
| BN | Mike Wallace WR | 1.50 |
| BN | Alex Smith QB | 15.10 |
| Bench | ||
| Pos | Player | Points |
| BN | David Johnson RB | 0.00 |
| BN | Derrick Henry RB | 6.90 |
| BN | Terrance West RB | 0.60 |
| BN | Devontae Booker RB | 0.00 |
| BN | Donte Moncrief WR | 5.40 |
| BN | Willie Snead WR | 0.00 |
| BN | Cameron Brate TE | 11.30 |
| BN | Philadelphia Eagles DST | 1.00 |
| BN | DeAngelo Henderson RB | 0.10 |
| BN | Jay Cutler QB | 11.70 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 26.80 | 100% |
| RB | LeGarrette Blount RB | 12.70 | 61.4% |
| RB | Frank Gore RB | 12.20 | |
| WR | Taylor Gabriel WR | 16.40 | 86.6% |
| WR | DeSean Jackson WR | 16.40 | |
| TE | Jimmy Graham TE | 10.70 | 100% |
| FLEX | Golden Tate WR | 15.80 | 58.5% |
| FLEX | Kenny Britt WR | 12.90 | |
| DST | Kansas City Chiefs DST | 11.00 | 100% |
| Total | 134.9 | 80.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jay Cutler QB | 11.70 | 29.9% |
| RB | Jordan Howard RB | 29.10 | 100% |
| RB | Carlos Hyde RB | 22.90 | |
| WR | Odell Beckham WR | 24.40 | 100% |
| WR | Tyler Lockett WR | 5.60 | |
| TE | Cameron Brate TE | 11.30 | 5.3% |
| FLEX | Jordan Matthews TE | 7.60 | 92.4% |
| FLEX | Derrick Henry RB | 6.90 | |
| DST | Los Angeles Rams DST | 2.00 | 100% |
| Total | 121.5 | 83.5% | |