| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 3.50 |
| RB | Jerick McKinnon RB | 6.50 |
| RB | Latavius Murray RB | 3.00 |
| WR | Randall Cobb WR | 7.90 |
| WR | Terrance Williams WR | 4.00 |
| TE | Evan Engram TE | 7.40 |
| FLEX | Dion Lewis RB | 11.60 |
| FLEX | Kerwynn Williams RB | 9.30 |
| DST | Pittsburgh Steelers DST | -3.00 |
| Total | 50.2 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 20.80 |
| RB | Jordan Howard RB | 28.00 |
| RB | Carlos Hyde RB | 13.80 |
| WR | Tyler Lockett WR | 22.50 |
| WR | Jordan Matthews WR | 0.00 |
| TE | Travis Kelce TE | 10.90 |
| FLEX | Devontae Booker RB | 4.40 |
| FLEX | Derrick Henry RB | 8.00 |
| DST | Philadelphia Eagles DST | 9.00 |
| Total | 117.4 | |
| Bench | ||
| Pos | Player | Points |
| BN | Arizona Cardinals DST | 12.00 |
| BN | Kelvin Benjamin WR | 11.30 |
| BN | Pierre Garcon WR | 0.00 |
| BN | Tyrell Williams WR | 21.20 |
| BN | Charcandrick West RB | 8.50 |
| BN | Eddie Lacy RB | 0.00 |
| BN | Greg Olsen TE | 0.00 |
| BN | Ed Dickson TE | 0.00 |
| BN | Chris Hogan WR | 0.60 |
| BN | Josh McCown QB | -1.50 |
| Bench | ||
| Pos | Player | Points |
| BN | David Johnson RB | 0.00 |
| BN | Theo Riddick RB | 24.30 |
| BN | Terrance West RB | 0.00 |
| BN | Odell Beckham WR | 0.00 |
| BN | Donte Moncrief WR | 0.00 |
| BN | Willie Snead WR | 0.50 |
| BN | Cameron Brate TE | 1.60 |
| BN | Ben Roethlisberger QB | 28.70 |
| BN | Los Angeles Rams DST | 4.00 |
| BN | Jay Cutler QB | 22.90 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Marcus Mariota QB | 3.50 | 100% |
| RB | Dion Lewis RB | 11.60 | 45.5% |
| RB | Kerwynn Williams RB | 9.30 | |
| WR | Tyrell Williams WR | 21.20 | 36.6% |
| WR | Kelvin Benjamin WR | 11.30 | |
| TE | Evan Engram TE | 7.40 | 100% |
| FLEX | Charcandrick West RB | 8.50 | 127.4% |
| FLEX | Randall Cobb WR | 7.90 | |
| DST | Arizona Cardinals DST | 12.00 | -25% |
| Total | 92.7 | 54.2% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Ben Roethlisberger QB | 28.70 | 72.5% |
| RB | Jordan Howard RB | 28.00 | 79.9% |
| RB | Theo Riddick RB | 24.30 | |
| WR | Tyler Lockett WR | 22.50 | 97.8% |
| WR | Willie Snead WR | 0.50 | |
| TE | Travis Kelce TE | 10.90 | 100% |
| FLEX | Carlos Hyde RB | 13.80 | 56.9% |
| FLEX | Derrick Henry RB | 8.00 | |
| DST | Philadelphia Eagles DST | 9.00 | 100% |
| Total | 145.7 | 80.6% | |