| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 17.10 |
| RB | Mark Ingram RB | 29.60 |
| RB | Rex Burkhead RB | 8.20 |
| WR | Antonio Brown WR | 3.40 |
| WR | Jordy Nelson WR | 4.30 |
| TE | Delanie Walker TE | 10.20 |
| FLEX | Michael Crabtree WR | 19.40 |
| FLEX | Robby Anderson WR | 6.50 |
| DST | Miami Dolphins DST | 2.00 |
| Total | 100.7 | |
| Starters | ||
| Pos | Player | Points |
| QB | Tom Brady QB | 15.70 |
| RB | Melvin Gordon RB | 25.90 |
| RB | LeSean McCoy RB | 23.60 |
| WR | Dez Bryant WR | 6.50 |
| WR | Larry Fitzgerald WR | 8.50 |
| TE | Jack Doyle TE | 8.20 |
| FLEX | Alfred Morris RB | 7.10 |
| FLEX | Kenyan Drake RB | 20.30 |
| DST | Jacksonville Jaguars DST | 12.00 |
| Total | 127.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Joe Mixon RB | 0.00 |
| BN | Martavis Bryant WR | 13.90 |
| BN | Deshaun Watson QB | 0.00 |
| BN | Matt Breida RB | 4.90 |
| BN | Los Angeles Chargers DST | -1.00 |
| BN | Damien Williams RB | 0.00 |
| BN | Tevin Coleman RB | 0.00 |
| BN | Will Fuller WR | 7.70 |
| BN | Chris Carson RB | 0.00 |
| BN | Danny Woodhead RB | 6.20 |
| Bench | ||
| Pos | Player | Points |
| BN | Dak Prescott QB | 13.70 |
| BN | Ezekiel Elliott RB | 0.00 |
| BN | James White RB | 1.80 |
| BN | Amari Cooper WR | 0.00 |
| BN | Kyle Rudolph TE | 8.70 |
| BN | Minnesota Vikings DST | 19.00 |
| BN | Robert Woods WR | 13.50 |
| BN | Rishard Matthews WR | 18.50 |
| BN | Darren McFadden RB | 0.00 |
| BN | Sammy Watkins WR | 2.40 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 17.10 | 100% |
| RB | Mark Ingram RB | 29.60 | 100% |
| RB | Rex Burkhead RB | 8.20 | |
| WR | Michael Crabtree WR | 19.40 | 23.1% |
| WR | Martavis Bryant WR | 13.90 | |
| TE | Delanie Walker TE | 10.20 | 100% |
| FLEX | Will Fuller WR | 7.70 | 182.4% |
| FLEX | Robby Anderson WR | 6.50 | |
| DST | Miami Dolphins DST | 2.00 | 100% |
| Total | 114.6 | 87.9% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Tom Brady QB | 15.70 | 100% |
| RB | Melvin Gordon RB | 25.90 | 100% |
| RB | LeSean McCoy RB | 23.60 | |
| WR | Rishard Matthews WR | 18.50 | 46.9% |
| WR | Robert Woods WR | 13.50 | |
| TE | Kyle Rudolph TE | 8.70 | 94.3% |
| FLEX | Kenyan Drake RB | 20.30 | 95.1% |
| FLEX | Larry Fitzgerald WR | 8.50 | |
| DST | Minnesota Vikings DST | 19.00 | 63.2% |
| Total | 153.7 | 83.1% | |