| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 18.00 |
| RB | Jerick McKinnon RB | 17.30 |
| RB | Latavius Murray RB | 16.90 |
| WR | Randall Cobb WR | 17.90 |
| WR | Terrance Williams WR | 3.40 |
| TE | Evan Engram TE | 14.10 |
| FLEX | Dion Lewis RB | 18.20 |
| FLEX | Kerwynn Williams RB | 6.10 |
| DST | Pittsburgh Steelers DST | 3.00 |
| Total | 114.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 7.10 |
| RB | Jordan Howard RB | 8.30 |
| RB | Carlos Hyde RB | 4.90 |
| WR | Tyler Lockett WR | 8.60 |
| WR | Willie Snead WR | 2.80 |
| TE | Travis Kelce TE | 7.60 |
| FLEX | Derrick Henry RB | 3.80 |
| FLEX | Theo Riddick RB | 5.60 |
| DST | Philadelphia Eagles DST | 2.00 |
| Total | 50.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | Arizona Cardinals DST | 5.00 |
| BN | Kelvin Benjamin WR | 3.00 |
| BN | Pierre Garcon WR | 0.00 |
| BN | Tyrell Williams WR | 4.60 |
| BN | Charcandrick West RB | 0.60 |
| BN | Eddie Lacy RB | 0.00 |
| BN | Greg Olsen TE | 22.10 |
| BN | Ed Dickson TE | 0.00 |
| BN | Chris Hogan WR | 0.00 |
| BN | Josh McCown QB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Devontae Booker RB | 6.60 |
| BN | David Johnson RB | 0.00 |
| BN | Terrance West RB | 0.00 |
| BN | Odell Beckham WR | 0.00 |
| BN | Jordan Matthews TE | 0.00 |
| BN | Donte Moncrief WR | 0.00 |
| BN | Cameron Brate TE | 6.90 |
| BN | Ben Roethlisberger QB | 18.20 |
| BN | Los Angeles Rams DST | 19.00 |
| BN | Jay Cutler QB | 5.80 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Marcus Mariota QB | 18.00 | 100% |
| RB | Dion Lewis RB | 18.20 | 96.3% |
| RB | Jerick McKinnon RB | 17.30 | |
| WR | Randall Cobb WR | 17.90 | 94.7% |
| WR | Tyrell Williams WR | 4.60 | |
| TE | Greg Olsen TE | 22.10 | 63.8% |
| FLEX | Latavius Murray RB | 16.90 | 78.4% |
| FLEX | Evan Engram TE | 14.10 | |
| DST | Arizona Cardinals DST | 5.00 | 60% |
| Total | 134.1 | 85.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Ben Roethlisberger QB | 18.20 | 39% |
| RB | Jordan Howard RB | 8.30 | 88.6% |
| RB | Devontae Booker RB | 6.60 | |
| WR | Tyler Lockett WR | 8.60 | 100% |
| WR | Willie Snead WR | 2.80 | |
| TE | Travis Kelce TE | 7.60 | 100% |
| FLEX | Cameron Brate TE | 6.90 | 75.2% |
| FLEX | Theo Riddick RB | 5.60 | |
| DST | Los Angeles Rams DST | 19.00 | 10.5% |
| Total | 83.6 | 60.6% | |