| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 11.40 |
| RB | Latavius Murray RB | 8.00 |
| RB | Jerick McKinnon RB | 5.60 |
| WR | Tyrell Williams WR | 7.50 |
| WR | Randall Cobb WR | 3.60 |
| TE | Evan Engram TE | 1.70 |
| FLEX | Dion Lewis RB | 31.90 |
| FLEX | Greg Olsen TE | 4.20 |
| DST | Pittsburgh Steelers DST | 17.00 |
| Total | 90.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Ben Roethlisberger QB | 16.90 |
| RB | Carlos Hyde RB | 14.80 |
| RB | Jordan Howard RB | 16.40 |
| WR | Tyler Lockett WR | 1.90 |
| WR | Willie Snead WR | 1.10 |
| TE | Travis Kelce TE | 12.70 |
| FLEX | Derrick Henry RB | 3.60 |
| FLEX | Theo Riddick RB | 5.40 |
| DST | Philadelphia Eagles DST | 22.00 |
| Total | 94.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Kelvin Benjamin WR | 9.50 |
| BN | Chris Hogan WR | 0.00 |
| BN | Pierre Garcon WR | 0.00 |
| BN | Arizona Cardinals DST | 21.00 |
| BN | Charcandrick West RB | 4.30 |
| BN | Kerwynn Williams RB | 7.50 |
| BN | Ed Dickson TE | 0.00 |
| BN | Josh McCown QB | 0.00 |
| BN | Eddie Lacy RB | 0.00 |
| BN | Terrance Williams WR | 6.30 |
| Bench | ||
| Pos | Player | Points |
| BN | Philip Rivers QB | 15.60 |
| BN | David Johnson RB | 0.00 |
| BN | Terrance West RB | 0.00 |
| BN | Devontae Booker RB | 8.90 |
| BN | Odell Beckham WR | 0.00 |
| BN | Jordan Matthews TE | 0.00 |
| BN | Donte Moncrief WR | 0.00 |
| BN | Cameron Brate TE | 2.80 |
| BN | Los Angeles Rams DST | 3.00 |
| BN | Jay Cutler QB | 15.30 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Marcus Mariota QB | 11.40 | 100% |
| RB | Dion Lewis RB | 31.90 | 34.1% |
| RB | Latavius Murray RB | 8.00 | |
| WR | Kelvin Benjamin WR | 9.50 | 65.3% |
| WR | Tyrell Williams WR | 7.50 | |
| TE | Greg Olsen TE | 4.20 | 40.5% |
| FLEX | Kerwynn Williams RB | 7.50 | 261.6% |
| FLEX | Terrance Williams WR | 6.30 | |
| DST | Arizona Cardinals DST | 21.00 | 81% |
| Total | 107.3 | 84.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Ben Roethlisberger QB | 16.90 | 100% |
| RB | Jordan Howard RB | 16.40 | 100% |
| RB | Carlos Hyde RB | 14.80 | |
| WR | Tyler Lockett WR | 1.90 | 100% |
| WR | Willie Snead WR | 1.10 | |
| TE | Travis Kelce TE | 12.70 | 100% |
| FLEX | Devontae Booker RB | 8.90 | 62.9% |
| FLEX | Theo Riddick RB | 5.40 | |
| DST | Philadelphia Eagles DST | 22.00 | 100% |
| Total | 100.1 | 94.7% | |