| Starters | ||
| Pos | Player | Points |
| QB | Tom Brady QB | 21.28 |
| RB | Ezekiel Elliott RB | 16.10 |
| RB | Melvin Gordon RB | 23.10 |
| WR | Antonio Brown WR | 19.80 |
| WR | Michael Crabtree WR | 11.30 |
| TE | Delanie Walker TE | 7.20 |
| FLEX | Robert Woods WR | 5.80 |
| FLEX | Rex Burkhead RB | 7.40 |
| DST | Minnesota Vikings DST | 18.00 |
| Total | 129.98 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 29.56 |
| RB | Todd Gurley RB | 22.20 |
| RB | Chris Thompson RB | 21.80 |
| WR | Stefon Diggs WR | 12.60 |
| WR | Keenan Allen WR | 20.80 |
| TE | O.J. Howard TE | 6.40 |
| FLEX | Nelson Agholor WR | 9.50 |
| FLEX | Cooper Kupp WR | 15.30 |
| DST | New Orleans Saints DST | -9.00 |
| Total | 129.16 | |
| Bench | ||
| Pos | Player | Points |
| BN | Dak Prescott QB | 8.70 |
| BN | Jacksonville Jaguars DST | 13.00 |
| BN | Sammy Watkins WR | 3.60 |
| BN | Brandon Marshall WR | 12.10 |
| BN | Marquise Goodwin WR | 0.00 |
| BN | Ryan Grant WR | 9.90 |
| BN | Matt Breida RB | 5.60 |
| BN | Albert Wilson WR | 5.30 |
| BN | Ricky Seals-Jones TE | 3.40 |
| BN | Justin Jackson RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Hunter Henry TE | 0.00 |
| BN | Josh Doctson WR | 1.60 |
| BN | Atlanta Falcons DST | 8.00 |
| BN | John Brown WR | 12.00 |
| BN | LeGarrette Blount RB | -0.30 |
| BN | Doug Martin RB | 2.70 |
| BN | Josh Rosen QB | 0.00 |
| BN | Sam Darnold QB | 13.82 |
| BN | Ronald Jones II RB | 0.00 |
| BN | JMon Moore WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Tom Brady QB | 21.28 | 100% |
| RB | Melvin Gordon RB | 23.10 | 100% |
| RB | Ezekiel Elliott RB | 16.10 | |
| WR | Antonio Brown WR | 19.80 | 97.5% |
| WR | Brandon Marshall WR | 12.10 | |
| TE | Delanie Walker TE | 7.20 | 100% |
| FLEX | Michael Crabtree WR | 11.30 | 62.3% |
| FLEX | Ryan Grant WR | 9.90 | |
| DST | Minnesota Vikings DST | 18.00 | 100% |
| Total | 138.78 | 93.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 29.56 | 100% |
| RB | Todd Gurley RB | 22.20 | 100% |
| RB | Chris Thompson RB | 21.80 | |
| WR | Keenan Allen WR | 20.80 | 92.5% |
| WR | Cooper Kupp WR | 15.30 | |
| TE | O.J. Howard TE | 6.40 | 100% |
| FLEX | Stefon Diggs WR | 12.60 | 100.8% |
| FLEX | John Brown WR | 12.00 | |
| DST | Atlanta Falcons DST | 8.00 | -112.5% |
| Total | 148.66 | 86.9% | |