| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 17.62 |
| RB | Todd Gurley RB | 30.80 |
| RB | Chris Thompson RB | 15.80 |
| WR | Stefon Diggs WR | 31.40 |
| WR | Keenan Allen WR | 10.95 |
| TE | O.J. Howard TE | 17.10 |
| FLEX | Nelson Agholor WR | 19.00 |
| FLEX | Cooper Kupp WR | 9.30 |
| DST | New Orleans Saints DST | 5.00 |
| Total | 156.97 | |
| Starters | ||
| Pos | Player | Points |
| QB | Mitch Trubisky QB | 14.40 |
| RB | Isaiah Crowell RB | 4.90 |
| RB | Marshawn Lynch RB | 13.80 |
| WR | Jamison Crowder WR | 4.70 |
| WR | Michael Thomas WR | 24.90 |
| TE | Jonnu Smith TE | 0.00 |
| FLEX | Peyton Barber RB | 3.40 |
| FLEX | Corey Davis WR | 8.00 |
| DST | Denver Broncos DST | 2.00 |
| Total | 76.1 | |
| Bench | ||
| Pos | Player | Points |
| BN | Tavon Austin WR | 16.40 |
| BN | Hunter Henry TE | 0.00 |
| BN | Josh Doctson WR | 5.70 |
| BN | Atlanta Falcons DST | 1.00 |
| BN | John Brown WR | 17.20 |
| BN | LeGarrette Blount RB | 4.00 |
| BN | Doug Martin RB | 2.90 |
| BN | Josh Rosen QB | 0.00 |
| BN | Sam Darnold QB | 13.46 |
| BN | Ronald Jones II RB | 0.00 |
| BN | JMon Moore WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Andrew Luck QB | 11.36 |
| BN | Josh Gordon WR | |
| BN | Jameis Winston QB | 0.00 |
| BN | Alshon Jeffery WR | 0.00 |
| BN | Tyler Eifert TE | 3.30 |
| BN | Jimmy Garoppolo QB | 16.64 |
| BN | Marlon Mack RB | 4.10 |
| BN | Austin Seferian-Jenkins TE | 9.80 |
| BN | Tennessee Titans DST | 4.00 |
| BN | Ito Smith RB | 5.90 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 17.62 | 100% |
| RB | Todd Gurley RB | 30.80 | 100% |
| RB | Chris Thompson RB | 15.80 | |
| WR | Stefon Diggs WR | 31.40 | 84% |
| WR | Nelson Agholor WR | 19.00 | |
| TE | O.J. Howard TE | 17.10 | 100% |
| FLEX | John Brown WR | 17.20 | 84.2% |
| FLEX | Tavon Austin WR | 16.40 | |
| DST | New Orleans Saints DST | 5.00 | 100% |
| Total | 170.32 | 92.2% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 16.64 | 86.5% |
| RB | Marshawn Lynch RB | 13.80 | 94.9% |
| RB | Ito Smith RB | 5.90 | |
| WR | Michael Thomas WR | 24.90 | 90% |
| WR | Corey Davis WR | 8.00 | |
| TE | Austin Seferian-Jenkins TE | 9.80 | 0% |
| FLEX | Jake Butt TE | 6.80 | 97.4% |
| FLEX | Isaiah Crowell RB | 4.90 | |
| DST | Tennessee Titans DST | 4.00 | 50% |
| Total | 94.74 | 80.3% | |