| Starters | ||
| Pos | Player | Points |
| QB | Jimmy Garoppolo QB | 22.30 |
| RB | Isaiah Crowell RB | 18.10 |
| RB | Marshawn Lynch RB | 16.10 |
| WR | Jamison Crowder WR | 12.50 |
| WR | Michael Thomas WR | 17.90 |
| TE | Tyler Eifert TE | 10.40 |
| FLEX | Peyton Barber RB | 3.30 |
| FLEX | Corey Davis WR | 4.40 |
| DST | Tennessee Titans DST | 11.00 |
| Total | 116 | |
| Starters | ||
| Pos | Player | Points |
| QB | Ben Roethlisberger QB | 24.00 |
| RB | Tevin Coleman RB | 11.70 |
| RB | Kenyan Drake RB | 2.00 |
| WR | Will Fuller WR | 18.60 |
| WR | Amari Cooper WR | 2.70 |
| TE | Eric Ebron TE | 5.80 |
| FLEX | Giovani Bernard RB | 17.10 |
| FLEX | Corey Clement RB | 9.25 |
| DST | Cleveland Browns DST | 11.00 |
| Total | 102.15 | |
| Bench | ||
| Pos | Player | Points |
| BN | Andrew Luck QB | 13.90 |
| BN | Denver Broncos DST | 6.00 |
| BN | Josh Gordon WR | 0.00 |
| BN | Jameis Winston QB | 0.00 |
| BN | Alshon Jeffery WR | 0.00 |
| BN | Mitch Trubisky QB | 5.60 |
| BN | Marlon Mack RB | 0.00 |
| BN | Jonnu Smith TE | 1.40 |
| BN | Austin Seferian-Jenkins TE | 3.30 |
| BN | Ito Smith RB | 5.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Mark Ingram RB | 0.00 |
| BN | Kyle Rudolph TE | 13.30 |
| BN | LeSean McCoy RB | 0.00 |
| BN | Julian Edelman WR | 0.00 |
| BN | Deshaun Watson QB | 25.00 |
| BN | Joe Mixon RB | 0.00 |
| BN | Chris Godwin WR | 13.90 |
| BN | Chris Carson RB | 19.40 |
| BN | D.J. Moore WR | 1.00 |
| BN | Calvin Ridley WR | 37.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 22.30 | 100% |
| RB | Isaiah Crowell RB | 18.10 | 100% |
| RB | Marshawn Lynch RB | 16.10 | |
| WR | Michael Thomas WR | 17.90 | 100% |
| WR | Jamison Crowder WR | 12.50 | |
| TE | Tyler Eifert TE | 10.40 | 100% |
| FLEX | Ito Smith RB | 5.00 | 81.9% |
| FLEX | Corey Davis WR | 4.40 | |
| DST | Tennessee Titans DST | 11.00 | 100% |
| Total | 117.7 | 98.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Deshaun Watson QB | 25.00 | 96% |
| RB | Chris Carson RB | 19.40 | 37.5% |
| RB | Giovani Bernard RB | 17.10 | |
| WR | Calvin Ridley WR | 37.00 | 38.3% |
| WR | Will Fuller WR | 18.60 | |
| TE | Kyle Rudolph TE | 13.30 | 43.6% |
| FLEX | Chris Godwin WR | 13.90 | 102.9% |
| FLEX | Tevin Coleman RB | 11.70 | |
| DST | Cleveland Browns DST | 11.00 | 100% |
| Total | 167 | 61.2% | |