| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 10.00 |
| RB | Carlos Hyde RB | 23.30 |
| RB | Bilal Powell RB | 7.30 |
| WR | Jarvis Landry WR | 16.80 |
| WR | Golden Tate WR | 9.90 |
| TE | George Kittle TE | 12.40 |
| FLEX | Larry Fitzgerald WR | 1.90 |
| FLEX | Saquon Barkley RB | 20.20 |
| DST | Los Angeles Rams DST | 13.00 |
| Total | 114.8 | |
| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 17.50 |
| RB | Alfred Morris RB | 12.70 |
| RB | Latavius Murray RB | 5.60 |
| WR | Randall Cobb WR | 3.75 |
| WR | Nelson Agholor WR | 4.40 |
| TE | O.J. Howard TE | 10.20 |
| FLEX | Dion Lewis RB | 5.50 |
| FLEX | Chris Hogan WR | 4.60 |
| DST | Arizona Cardinals DST | 8.00 |
| Total | 72.25 | |
| Bench | ||
| Pos | Player | Points |
| BN | Cameron Meredith WR | 7.60 |
| BN | Trey Burton TE | 7.50 |
| BN | Allen Hurns WR | 3.20 |
| BN | Alex Smith QB | 16.80 |
| BN | Ty Montgomery RB | 10.65 |
| BN | Nick Chubb RB | 0.60 |
| BN | Rashaad Penny RB | 0.50 |
| BN | Nyheim Hines RB | 6.80 |
| BN | Courtland Sutton WR | 4.70 |
| BN | Christian Kirk WR | 12.50 |
| Bench | ||
| Pos | Player | Points |
| BN | Pittsburgh Steelers DST | 12.00 |
| BN | Jordy Nelson WR | 26.30 |
| BN | Kelvin Benjamin WR | 4.40 |
| BN | Blake Bortles QB | 8.90 |
| BN | DeMarco Murray RB | 0.00 |
| BN | Greg Olsen TE | 0.00 |
| BN | Paul Richardson WR | 11.10 |
| BN | Ian Thomas TE | 3.50 |
| BN | TreQuan Smith WR | 0.00 |
| BN | Antonio Callaway WR | 4.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Alex Smith QB | 16.80 | 59.5% |
| RB | Carlos Hyde RB | 23.30 | 70.3% |
| RB | Saquon Barkley RB | 20.20 | |
| WR | Jakeem Grant WR | 25.25 | 63.5% |
| WR | Jarvis Landry WR | 16.80 | |
| TE | George Kittle TE | 12.40 | 100% |
| FLEX | Christian Kirk WR | 12.50 | 95.5% |
| FLEX | Ty Montgomery RB | 10.65 | |
| DST | Los Angeles Rams DST | 13.00 | 100% |
| Total | 150.9 | 76.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matthew Stafford QB | 17.50 | 100% |
| RB | Alfred Morris RB | 12.70 | 100% |
| RB | Latavius Murray RB | 5.60 | |
| WR | Jordy Nelson WR | 26.30 | 21.8% |
| WR | Paul Richardson WR | 11.10 | |
| TE | O.J. Howard TE | 10.20 | 100% |
| FLEX | Dion Lewis RB | 5.50 | 100% |
| FLEX | Tyrell Williams WR | 4.60 | |
| DST | Pittsburgh Steelers DST | 12.00 | 66.7% |
| Total | 105.5 | 68.5% | |