| Starters | ||
| Pos | Player | Points |
| QB | Ryan Tannehill QB | 0.00 |
| RB | Isaiah Crowell RB | 0.80 |
| RB | Marshawn Lynch RB | 17.20 |
| WR | Michael Thomas WR | 6.70 |
| WR | Corey Davis WR | 26.60 |
| TE | Tyler Eifert TE | 11.80 |
| FLEX | Josh Gordon WR | 4.20 |
| FLEX | Alshon Jeffery WR | 20.50 |
| DST | Tennessee Titans DST | 3.00 |
| Total | 90.8 | |
| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 9.00 |
| RB | Alvin Kamara RB | 38.60 |
| RB | Kareem Hunt RB | 25.00 |
| WR | A.J. Green WR | 15.80 |
| WR | JuJu Smith-Schuster WR | 8.00 |
| TE | Jimmy Graham TE | 9.60 |
| FLEX | DeSean Jackson WR | 13.80 |
| FLEX | Alex Collins RB | 9.00 |
| DST | Philadelphia Eagles DST | 4.00 |
| Total | 132.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Andrew Luck QB | 35.70 |
| BN | Denver Broncos DST | -2.00 |
| BN | Peyton Barber RB | 3.50 |
| BN | Jameis Winston QB | 6.50 |
| BN | Jamison Crowder WR | 0.00 |
| BN | Ed Dickson TE | 0.00 |
| BN | Mitch Trubisky QB | 43.50 |
| BN | Marlon Mack RB | 0.00 |
| BN | Austin Seferian-Jenkins TE | 3.40 |
| BN | Ito Smith RB | 12.30 |
| Bench | ||
| Pos | Player | Points |
| BN | Tyler Boyd WR | 15.50 |
| BN | Tyrod Taylor QB | 0.00 |
| BN | Devin Funchess TE | 0.00 |
| BN | Doug Baldwin WR | 6.60 |
| BN | Javorius Allen RB | 5.70 |
| BN | Charles Clay TE | 6.00 |
| BN | Jared Goff QB | 39.30 |
| BN | Kerryon Johnson RB | 12.10 |
| BN | Jordan Wilkins RB | 1.60 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Mitch Trubisky QB | 43.50 | 0% |
| RB | Marshawn Lynch RB | 17.20 | 61% |
| RB | Ito Smith RB | 12.30 | |
| WR | Corey Davis WR | 26.60 | 70.7% |
| WR | Alshon Jeffery WR | 20.50 | |
| TE | Tyler Eifert TE | 11.80 | 100% |
| FLEX | Michael Thomas WR | 6.70 | 226.6% |
| FLEX | Josh Gordon WR | 4.20 | |
| DST | Tennessee Titans DST | 3.00 | 100% |
| Total | 145.8 | 62.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 39.30 | 22.9% |
| RB | Alvin Kamara RB | 38.60 | 100% |
| RB | Kareem Hunt RB | 25.00 | |
| WR | A.J. Green WR | 15.80 | 76% |
| WR | Tyler Boyd WR | 15.50 | |
| TE | Jimmy Graham TE | 9.60 | 100% |
| FLEX | DeSean Jackson WR | 13.80 | 88% |
| FLEX | Kerryon Johnson RB | 12.10 | |
| DST | Philadelphia Eagles DST | 4.00 | 100% |
| Total | 173.7 | 76.5% | |