| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 21.70 |
| RB | Jordan Howard RB | 2.50 |
| RB | David Johnson RB | 16.70 |
| WR | Odell Beckham WR | 10.50 |
| WR | Tyler Lockett WR | 9.75 |
| TE | Travis Kelce TE | 17.30 |
| FLEX | James White RB | 27.20 |
| FLEX | Austin Ekeler RB | 12.60 |
| DST | Green Bay Packers DST | 21.00 |
| Total | 139.25 | |
| Starters | ||
| Pos | Player | Points |
| QB | Matt Ryan QB | 29.30 |
| RB | Leonard Fournette RB | 4.00 |
| WR | DeAndre Hopkins WR | 27.90 |
| WR | Kenny Golladay WR | 9.40 |
| WR | Sony Michel WR | 17.20 |
| TE | Benjamin Watson TE | 2.80 |
| FLEX | Julio Jones WR | 21.80 |
| FLEX | Sterling Shepard WR | 20.70 |
| DST | Chicago Bears DST | 13.00 |
| Total | 146.1 | |
| Bench | ||
| Pos | Player | Points |
| BN | Derrick Henry RB | 4.10 |
| BN | Theo Riddick RB | 4.70 |
| BN | Donte Moncrief WR | 19.40 |
| BN | Cameron Brate TE | 10.40 |
| BN | Cam Newton QB | 0.00 |
| BN | Taylor Gabriel WR | 26.90 |
| BN | Carolina Panthers DST | 0.00 |
| BN | Dallas Goedert TE | 2.30 |
| BN | Anthony Miller WR | 0.00 |
| BN | James Washington WR | 2.00 |
| Bench | ||
| Pos | Player | Points |
| BN | T.J. Yeldon RB | 21.50 |
| BN | Rishard Matthews WR | 0.00 |
| BN | Jordan Reed TE | 0.00 |
| BN | Pierre Garcon WR | 7.20 |
| BN | Duke Johnson RB | 11.60 |
| BN | Houston Texans DST | 8.00 |
| BN | Evan Engram TE | 0.00 |
| BN | Mike Williams WR | 2.00 |
| BN | Will Dissly TE | 1.00 |
| BN | Phillip Lindsay RB | 16.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 21.70 | 100% |
| RB | James White RB | 27.20 | 43.7% |
| RB | David Johnson RB | 16.70 | |
| WR | Taylor Gabriel WR | 26.90 | 43.7% |
| WR | Donte Moncrief WR | 19.40 | |
| TE | Travis Kelce TE | 17.30 | 100% |
| FLEX | Austin Ekeler RB | 12.60 | 172.3% |
| FLEX | Odell Beckham WR | 10.50 | |
| DST | Green Bay Packers DST | 21.00 | 100% |
| Total | 173.3 | 80.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matt Ryan QB | 29.30 | 100% |
| RB | T.J. Yeldon RB | 21.50 | 10.3% |
| RB | Sony Michel RB | 17.20 | |
| WR | DeAndre Hopkins WR | 27.90 | 109.7% |
| WR | Julio Jones WR | 21.80 | |
| TE | Benjamin Watson TE | 2.80 | 100% |
| FLEX | Sterling Shepard WR | 20.70 | 114.2% |
| FLEX | Phillip Lindsay RB | 16.50 | |
| DST | Chicago Bears DST | 13.00 | 100% |
| Total | 170.7 | 85.6% | |