| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 27.20 |
| RB | Todd Gurley RB | 31.30 |
| RB | Chris Thompson RB | 9.20 |
| WR | Stefon Diggs WR | 16.60 |
| WR | Keenan Allen WR | 13.50 |
| TE | Rob Gronkowski TE | 10.50 |
| FLEX | John Brown WR | 7.80 |
| FLEX | Cooper Kupp WR | 18.00 |
| DST | New York Jets DST | 4.00 |
| Total | 138.1 | |
| Starters | ||
| Pos | Player | Points |
| QB | Cam Newton QB | 16.40 |
| RB | James White RB | 18.70 |
| RB | David Johnson RB | 20.10 |
| WR | Odell Beckham WR | 29.45 |
| WR | Tyler Lockett WR | 21.60 |
| TE | Travis Kelce TE | 12.50 |
| FLEX | Derrick Henry RB | 5.60 |
| FLEX | Austin Ekeler RB | 12.40 |
| DST | Carolina Panthers DST | 9.00 |
| Total | 145.75 | |
| Bench | ||
| Pos | Player | Points |
| BN | Tavon Austin WR | 6.00 |
| BN | Hunter Henry TE | 0.00 |
| BN | Josh Doctson WR | 0.00 |
| BN | LeGarrette Blount RB | 14.20 |
| BN | Doug Martin RB | 0.10 |
| BN | New Orleans Saints DST | 9.00 |
| BN | Josh Rosen QB | 10.50 |
| BN | Sam Darnold QB | 18.40 |
| BN | Ronald Jones II RB | 0.00 |
| BN | JMon Moore WR | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Philip Rivers QB | 21.40 |
| BN | Jordan Howard RB | 0.00 |
| BN | Theo Riddick RB | 3.30 |
| BN | Donte Moncrief WR | 10.60 |
| BN | Cameron Brate TE | 0.00 |
| BN | Taylor Gabriel WR | 0.00 |
| BN | Green Bay Packers DST | 4.00 |
| BN | Dallas Goedert TE | 2.60 |
| BN | Anthony Miller WR | 0.00 |
| BN | James Washington WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 27.20 | 100% |
| RB | Todd Gurley RB | 31.30 | 89% |
| RB | LeGarrette Blount RB | 14.20 | |
| WR | Cooper Kupp WR | 18.00 | 87% |
| WR | Stefon Diggs WR | 16.60 | |
| TE | Rob Gronkowski TE | 10.50 | 100% |
| FLEX | Keenan Allen WR | 13.50 | 113.7% |
| FLEX | Chris Thompson RB | 9.20 | |
| DST | New Orleans Saints DST | 9.00 | 44.4% |
| Total | 149.5 | 92.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 21.40 | 76.6% |
| RB | David Johnson RB | 20.10 | 100% |
| RB | James White RB | 18.70 | |
| WR | Odell Beckham WR | 29.45 | 100% |
| WR | Tyler Lockett WR | 21.60 | |
| TE | Travis Kelce TE | 12.50 | 100% |
| FLEX | Rashard Higgins WR | 14.10 | 67.9% |
| FLEX | Austin Ekeler RB | 12.40 | |
| DST | Carolina Panthers DST | 9.00 | 100% |
| Total | 159.25 | 91.5% | |