| Starters | ||
| Pos | Player | Points |
| QB | Marcus Mariota QB | 15.70 |
| RB | Dion Lewis RB | 10.40 |
| RB | Chris Johnson RB | 7.80 |
| WR | Kelvin Benjamin WR | 12.40 |
| WR | Pierre Garcon WR | 5.60 |
| TE | Evan Engram TE | 9.20 |
| FLEX | Chris Hogan WR | 14.50 |
| FLEX | Tyrell Williams WR | 20.00 |
| DST | Pittsburgh Steelers DST | 15.00 |
| Total | 110.6 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 19.90 |
| RB | Carlos Hyde RB | 12.00 |
| RB | Jordan Howard RB | 13.30 |
| WR | Odell Beckham WR | 12.50 |
| WR | Tyler Lockett WR | 11.90 |
| TE | Travis Kelce TE | 20.90 |
| FLEX | Theo Riddick RB | 1.70 |
| FLEX | Willie Snead WR | 0.00 |
| DST | Los Angeles Rams DST | 2.00 |
| Total | 94.2 | |
| Bench | ||
| Pos | Player | Points |
| BN | Carson Palmer QB | 16.40 |
| BN | Trevor Siemian QB | 11.30 |
| BN | Latavius Murray RB | 3.90 |
| BN | J.J. Nelson WR | 4.90 |
| BN | Arizona Cardinals DST | 6.00 |
| BN | Charcandrick West RB | 6.00 |
| BN | Kerwynn Williams RB | 1.80 |
| Bench | ||
| Pos | Player | Points |
| BN | David Johnson RB | 0.00 |
| BN | Derrick Henry RB | 0.70 |
| BN | Terrance West RB | -0.70 |
| BN | Devontae Booker RB | 1.40 |
| BN | Jordan Matthews TE | 8.00 |
| BN | Donte Moncrief WR | 10.50 |
| BN | Cameron Brate TE | 16.00 |
| BN | Philadelphia Eagles DST | 1.00 |
| BN | DeAngelo Henderson RB | 0.00 |
| BN | Jay Cutler QB | 5.10 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Carson Palmer QB | 16.40 | 95.7% |
| RB | Dion Lewis RB | 10.40 | 100% |
| RB | Chris Johnson RB | 7.80 | |
| WR | Tyrell Williams WR | 20.00 | 52.2% |
| WR | Chris Hogan WR | 14.50 | |
| TE | Evan Engram TE | 9.20 | 100% |
| FLEX | Kelvin Benjamin WR | 12.40 | 187.5% |
| FLEX | Charcandrick West RB | 6.00 | |
| DST | Pittsburgh Steelers DST | 15.00 | 100% |
| Total | 111.7 | 99% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 19.90 | 100% |
| RB | Jordan Howard RB | 13.30 | 100% |
| RB | Carlos Hyde RB | 12.00 | |
| WR | Odell Beckham WR | 12.50 | 100% |
| WR | Tyler Lockett WR | 11.90 | |
| TE | Travis Kelce TE | 20.90 | 100% |
| FLEX | Cameron Brate TE | 16.00 | 6.4% |
| FLEX | Donte Moncrief WR | 10.50 | |
| DST | Los Angeles Rams DST | 2.00 | 100% |
| Total | 119 | 79.2% | |