| Starters | ||
| Pos | Player | Points |
| QB | Blake Bortles QB | 1.40 |
| RB | Alfred Morris RB | 2.50 |
| RB | Latavius Murray RB | 21.30 |
| WR | Nelson Agholor WR | 5.00 |
| WR | Antonio Callaway WR | 1.90 |
| TE | Greg Olsen TE | 7.50 |
| FLEX | Kelvin Benjamin WR | 9.10 |
| FLEX | O.J. Howard TE | 9.20 |
| DST | Arizona Cardinals DST | 3.00 |
| Total | 60.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Cam Newton QB | 25.70 |
| RB | James White RB | 25.70 |
| RB | David Johnson RB | 8.50 |
| WR | Odell Beckham WR | 24.20 |
| WR | Taylor Gabriel WR | 4.10 |
| TE | Travis Kelce TE | 12.00 |
| FLEX | Jordan Howard RB | 11.30 |
| FLEX | Austin Ekeler RB | 9.30 |
| DST | Carolina Panthers DST | 7.00 |
| Total | 127.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Pittsburgh Steelers DST | 0.00 |
| BN | Jordy Nelson WR | 0.00 |
| BN | Randall Cobb WR | 0.00 |
| BN | DeMarco Murray RB | 0.00 |
| BN | Matthew Stafford QB | 17.60 |
| BN | Chris Hogan WR | 9.30 |
| BN | Paul Richardson WR | 0.00 |
| BN | Baker Mayfield QB | 20.90 |
| BN | Ian Thomas TE | 0.00 |
| BN | TreQuan Smith WR | 5.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Philip Rivers QB | 20.10 |
| BN | Derrick Henry RB | 13.50 |
| BN | Theo Riddick RB | 0.00 |
| BN | Tyler Lockett WR | 0.00 |
| BN | Donte Moncrief WR | 11.10 |
| BN | Cameron Brate TE | 1.80 |
| BN | Green Bay Packers DST | 0.00 |
| BN | Dallas Goedert TE | 12.30 |
| BN | Anthony Miller WR | 4.50 |
| BN | James Washington WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Baker Mayfield QB | 20.90 | 6.7% |
| RB | Latavius Murray RB | 21.30 | 100% |
| RB | Alfred Morris RB | 2.50 | |
| WR | Tyrell Williams WR | 19.80 | 23.7% |
| WR | Chris Hogan WR | 9.30 | |
| TE | O.J. Howard TE | 9.20 | 81.5% |
| FLEX | Kelvin Benjamin WR | 9.10 | 110.2% |
| FLEX | Greg Olsen TE | 7.50 | |
| DST | Arizona Cardinals DST | 3.00 | 100% |
| Total | 102.6 | 59.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Cam Newton QB | 25.70 | 100% |
| RB | James White RB | 25.70 | 87.2% |
| RB | Derrick Henry RB | 13.50 | |
| WR | Odell Beckham WR | 24.20 | 80.2% |
| WR | Donte Moncrief WR | 11.10 | |
| TE | Dallas Goedert TE | 12.30 | 97.6% |
| FLEX | Travis Kelce TE | 12.00 | 88.4% |
| FLEX | Jordan Howard RB | 11.30 | |
| DST | Carolina Panthers DST | 7.00 | 100% |
| Total | 142.8 | 89.5% | |