| Starters | ||
| Pos | Player | Points |
| QB | Jared Goff QB | 26.50 |
| RB | Alvin Kamara RB | 23.85 |
| RB | Kareem Hunt RB | 17.10 |
| WR | A.J. Green WR | 16.10 |
| WR | JuJu Smith-Schuster WR | 5.30 |
| TE | Jimmy Graham TE | 2.60 |
| FLEX | Tyler Boyd WR | 24.10 |
| FLEX | Kerryon Johnson RB | 12.10 |
| DST | Philadelphia Eagles DST | 6.00 |
| Total | 133.65 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 6.80 |
| RB | Todd Gurley RB | 30.50 |
| RB | Doug Martin RB | 7.90 |
| WR | Stefon Diggs WR | 22.90 |
| WR | John Brown WR | 4.30 |
| TE | Rob Gronkowski TE | 5.80 |
| FLEX | Chris Thompson RB | 3.20 |
| FLEX | Ronald Jones II RB | 0.60 |
| DST | New York Jets DST | 1.00 |
| Total | 83 | |
| Bench | ||
| Pos | Player | Points |
| BN | Russell Wilson QB | 23.40 |
| BN | Devin Funchess TE | 4.20 |
| BN | Doug Baldwin WR | 3.60 |
| BN | DeSean Jackson WR | 14.70 |
| BN | Javorius Allen RB | 9.30 |
| BN | Charles Clay TE | 5.10 |
| BN | Alex Collins RB | 11.30 |
| BN | Mike Davis RB | 0.00 |
| BN | Jordan Wilkins RB | 1.40 |
| Bench | ||
| Pos | Player | Points |
| BN | Hunter Henry TE | 0.00 |
| BN | Keenan Allen WR | 0.00 |
| BN | Josh Doctson WR | 7.40 |
| BN | LeGarrette Blount RB | 3.10 |
| BN | Gerald Everett TE | 2.70 |
| BN | Cooper Kupp WR | 0.00 |
| BN | New Orleans Saints DST | 11.00 |
| BN | Josh Rosen QB | 19.30 |
| BN | Sam Darnold QB | 12.30 |
| BN | JMon Moore WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 26.50 | 100% |
| RB | Alvin Kamara RB | 23.85 | 100% |
| RB | Kareem Hunt RB | 17.10 | |
| WR | Tyler Boyd WR | 24.10 | 53.2% |
| WR | A.J. Green WR | 16.10 | |
| TE | Charles Clay TE | 5.10 | 51% |
| FLEX | DeSean Jackson WR | 14.70 | 135.1% |
| FLEX | Kerryon Johnson RB | 12.10 | |
| DST | Philadelphia Eagles DST | 6.00 | 100% |
| Total | 145.55 | 91.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Josh Rosen QB | 19.30 | 35.2% |
| RB | Todd Gurley RB | 30.50 | 100% |
| RB | Doug Martin RB | 7.90 | |
| WR | Stefon Diggs WR | 22.90 | 89.8% |
| WR | Josh Doctson WR | 7.40 | |
| TE | Jordan Matthews TE | 11.30 | 51.3% |
| FLEX | Rob Gronkowski TE | 5.80 | 37.6% |
| FLEX | John Brown WR | 4.30 | |
| DST | New Orleans Saints DST | 11.00 | 9.1% |
| Total | 120.4 | 68.9% | |