| Starters | ||
| Pos | Player | Points |
| QB | Patrick Mahomes QB | 26.00 |
| RB | Lamar Miller RB | 19.30 |
| RB | Tarik Cohen RB | 19.30 |
| WR | Tyreek Hill WR | 9.25 |
| WR | Adam Thielen WR | 19.30 |
| TE | Jared Cook TE | 15.40 |
| FLEX | Dede Westbrook WR | 12.15 |
| FLEX | Keke Coutee WR | 0.00 |
| DST | New England Patriots DST | 17.00 |
| Total | 137.7 | |
| Starters | ||
| Pos | Player | Points |
| QB | Andrew Luck QB | 23.40 |
| RB | Peyton Barber RB | 14.50 |
| RB | Marlon Mack RB | 27.90 |
| WR | Alshon Jeffery WR | 5.50 |
| WR | Michael Thomas WR | 10.60 |
| TE | C.J. Uzomah TE | 0.00 |
| FLEX | Josh Gordon WR | 6.20 |
| FLEX | Ed Dickson TE | 12.40 |
| DST | Indianapolis Colts DST | 1.00 |
| Total | 101.5 | |
| Bench | ||
| Pos | Player | Points |
| BN | Jack Doyle TE | 16.00 |
| BN | Joe Flacco QB | 9.10 |
| BN | LeVeon Bell RB | 0.00 |
| BN | Cincinnati Bengals DST | 12.00 |
| BN | Austin Hooper TE | 0.00 |
| BN | Geronimo Allison WR | 1.90 |
| BN | Jamaal Williams RB | 6.90 |
| BN | Mack Hollins WR | 0.00 |
| BN | Kenny Stills WR | 0.00 |
| BN | Lamar Jackson QB | 8.40 |
| Bench | ||
| Pos | Player | Points |
| BN | Jameis Winston QB | 8.80 |
| BN | Jamison Crowder WR | 0.00 |
| BN | Marshawn Lynch RB | 0.00 |
| BN | Mitch Trubisky QB | 21.90 |
| BN | Corey Davis WR | 0.00 |
| BN | Tennessee Titans DST | 0.00 |
| BN | Derrius Guice RB | 0.00 |
| BN | Ito Smith RB | 0.00 |
| BN | Hayden Hurst TE | 9.90 |
| BN | Marquez Valdes-Scantling WR | 11.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Patrick Mahomes QB | 26.00 | 100% |
| RB | Tarik Cohen RB | 19.30 | 100% |
| RB | Lamar Miller RB | 19.30 | |
| WR | Adam Thielen WR | 19.30 | 90.8% |
| WR | Dede Westbrook WR | 12.15 | |
| TE | Jack Doyle TE | 16.00 | 96.3% |
| FLEX | Jared Cook TE | 15.40 | 44.5% |
| FLEX | Danny Amendola WR | 11.90 | |
| DST | New England Patriots DST | 17.00 | 100% |
| Total | 156.35 | 88.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Andrew Luck QB | 23.40 | 100% |
| RB | Marlon Mack RB | 27.90 | 100% |
| RB | Peyton Barber RB | 14.50 | |
| WR | Marquez Valdes-Scantling WR | 11.50 | 72.9% |
| WR | Michael Thomas WR | 10.60 | |
| TE | Ed Dickson TE | 12.40 | 0% |
| FLEX | Hayden Hurst TE | 9.90 | 115.5% |
| FLEX | Josh Gordon WR | 6.20 | |
| DST | Washington Commanders DST | 14.00 | 7.1% |
| Total | 130.4 | 77.8% | |