| Starters | ||
| Pos | Player | Points |
| QB | Matthew Stafford QB | 17.00 |
| RB | Alfred Morris RB | 2.80 |
| RB | Latavius Murray RB | 18.00 |
| WR | Nelson Agholor WR | 7.80 |
| WR | Antonio Callaway WR | 12.10 |
| TE | Greg Olsen TE | 13.60 |
| FLEX | Kelvin Benjamin WR | 5.50 |
| FLEX | O.J. Howard TE | 14.80 |
| DST | Arizona Cardinals DST | 9.00 |
| Total | 100.6 | |
| Starters | ||
| Pos | Player | Points |
| QB | Kirk Cousins QB | 20.70 |
| RB | Saquon Barkley RB | 15.60 |
| RB | Nick Chubb RB | 8.50 |
| WR | Jarvis Landry WR | 7.90 |
| WR | Christian Kirk WR | 11.70 |
| TE | George Kittle TE | 8.20 |
| FLEX | Golden Tate WR | 8.80 |
| FLEX | Jakeem Grant WR | 7.05 |
| DST | Los Angeles Rams DST | 6.00 |
| Total | 94.45 | |
| Bench | ||
| Pos | Player | Points |
| BN | Pittsburgh Steelers DST | 8.00 |
| BN | Jordy Nelson WR | 1.90 |
| BN | Randall Cobb WR | 6.00 |
| BN | Tyrell Williams WR | 0.00 |
| BN | Blake Bortles QB | 19.70 |
| BN | Chris Hogan WR | 5.90 |
| BN | Paul Richardson WR | 5.10 |
| BN | Baker Mayfield QB | 14.10 |
| BN | Ian Thomas TE | 2.00 |
| BN | TreQuan Smith WR | 3.30 |
| Bench | ||
| Pos | Player | Points |
| BN | Cameron Meredith WR | 0.00 |
| BN | Carlos Hyde RB | 1.10 |
| BN | Trey Burton TE | 3.30 |
| BN | Alex Smith QB | 12.40 |
| BN | Ty Montgomery RB | 2.70 |
| BN | Larry Fitzgerald WR | 22.20 |
| BN | Rashaad Penny RB | 0.85 |
| BN | Nyheim Hines RB | 9.50 |
| BN | Courtland Sutton WR | 9.30 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Blake Bortles QB | 19.70 | 86.3% |
| RB | Latavius Murray RB | 18.00 | 100% |
| RB | Alfred Morris RB | 2.80 | |
| WR | Antonio Callaway WR | 12.10 | 100% |
| WR | Nelson Agholor WR | 7.80 | |
| TE | O.J. Howard TE | 14.80 | 91.9% |
| FLEX | Greg Olsen TE | 13.60 | 96% |
| FLEX | DJ Chark Jr. WR | 7.55 | |
| DST | Arizona Cardinals DST | 9.00 | 100% |
| Total | 105.35 | 95.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kirk Cousins QB | 20.70 | 100% |
| RB | Saquon Barkley RB | 15.60 | 96% |
| RB | Nyheim Hines RB | 9.50 | |
| WR | Larry Fitzgerald WR | 22.20 | 50.8% |
| WR | DeVante Parker WR | 16.40 | |
| TE | George Kittle TE | 8.20 | 100% |
| FLEX | Christian Kirk WR | 11.70 | 75.5% |
| FLEX | Courtland Sutton WR | 9.30 | |
| DST | Los Angeles Rams DST | 6.00 | 100% |
| Total | 119.6 | 79% | |