| Starters | ||
| Pos | Player | Points |
| QB | Jared Goff QB | 29.30 |
| RB | Alvin Kamara RB | 31.60 |
| RB | Kareem Hunt RB | 32.60 |
| WR | Devin Funchess WR | 6.40 |
| WR | JuJu Smith-Schuster WR | 11.30 |
| TE | Jimmy Graham TE | 13.50 |
| FLEX | DeSean Jackson WR | 4.20 |
| FLEX | Kerryon Johnson RB | 5.90 |
| DST | Denver Broncos DST | 6.00 |
| Total | 140.8 | |
| Starters | ||
| Pos | Player | Points |
| QB | Tom Brady QB | 15.70 |
| RB | Ezekiel Elliott RB | 13.20 |
| RB | Melvin Gordon RB | 18.80 |
| WR | Antonio Brown WR | 12.70 |
| WR | Michael Crabtree WR | 4.70 |
| TE | Vance McDonald TE | 4.00 |
| FLEX | Robert Woods WR | 10.00 |
| FLEX | Sammy Watkins WR | 8.90 |
| DST | Minnesota Vikings DST | 23.00 |
| Total | 111 | |
| Bench | ||
| Pos | Player | Points |
| BN | A.J. Green WR | 0.00 |
| BN | Tyler Boyd WR | 0.00 |
| BN | Russell Wilson QB | 19.50 |
| BN | Philadelphia Eagles DST | 0.00 |
| BN | Doug Baldwin WR | 9.70 |
| BN | Javorius Allen RB | 3.90 |
| BN | Charles Clay TE | 0.00 |
| BN | Alex Collins RB | 10.40 |
| BN | Mike Davis RB | 0.00 |
| BN | Jordan Wilkins RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Wendell Smallwood RB | 0.00 |
| BN | Eli Manning QB | 0.00 |
| BN | Dak Prescott QB | 14.80 |
| BN | Jacksonville Jaguars DST | 0.00 |
| BN | Kenjon Barner RB | 0.40 |
| BN | Marquise Goodwin WR | 1.80 |
| BN | Ryan Grant WR | 0.00 |
| BN | Matt Breida RB | 5.20 |
| BN | Raheem Mostert RB | 14.60 |
| BN | Josh Adams RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 29.30 | 100% |
| RB | Kareem Hunt RB | 32.60 | 100% |
| RB | Alvin Kamara RB | 31.60 | |
| WR | JuJu Smith-Schuster WR | 11.30 | 84.3% |
| WR | Doug Baldwin WR | 9.70 | |
| TE | Jimmy Graham TE | 13.50 | 100% |
| FLEX | Alex Collins RB | 10.40 | 60.1% |
| FLEX | Devin Funchess TE | 6.40 | |
| DST | Denver Broncos DST | 6.00 | 100% |
| Total | 150.8 | 93.4% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Tom Brady QB | 15.70 | 100% |
| RB | Melvin Gordon RB | 18.80 | 95.8% |
| RB | Raheem Mostert RB | 14.60 | |
| WR | Curtis Samuel WR | 18.80 | 55.2% |
| WR | Antonio Brown WR | 12.70 | |
| TE | Vance McDonald TE | 4.00 | 100% |
| FLEX | Ezekiel Elliott RB | 13.20 | 81.5% |
| FLEX | Robert Woods WR | 10.00 | |
| DST | Minnesota Vikings DST | 23.00 | 100% |
| Total | 130.8 | 84.9% | |