| Starters | ||
| Pos | Player | Points |
| QB | Andrew Luck QB | 21.20 |
| RB | Isaiah Crowell RB | 10.70 |
| RB | Marlon Mack RB | 6.80 |
| WR | Josh Gordon WR | 10.10 |
| WR | Michael Thomas WR | 23.00 |
| TE | C.J. Uzomah TE | 3.80 |
| FLEX | Alshon Jeffery WR | 6.80 |
| FLEX | Marquez Valdes-Scantling WR | 7.40 |
| DST | Washington Commanders DST | 8.00 |
| Total | 97.8 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 28.90 |
| RB | Todd Gurley RB | 23.50 |
| RB | Doug Martin RB | 10.70 |
| WR | Josh Doctson WR | 12.60 |
| WR | Cooper Kupp WR | 6.40 |
| TE | Gerald Everett TE | 8.50 |
| FLEX | Jordan Howard RB | 3.70 |
| FLEX | Keenan Allen WR | 14.70 |
| DST | New York Jets DST | -7.00 |
| Total | 102 | |
| Bench | ||
| Pos | Player | Points |
| BN | Peyton Barber RB | 7.10 |
| BN | Jamison Crowder WR | 0.00 |
| BN | Indianapolis Colts DST | 1.00 |
| BN | Ed Dickson TE | 8.00 |
| BN | Mitch Trubisky QB | 36.00 |
| BN | Corey Davis WR | 22.00 |
| BN | Tennessee Titans DST | 8.00 |
| BN | Derrius Guice RB | 0.00 |
| BN | Ito Smith RB | 4.60 |
| BN | Chris Herndon IV TE | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Stefon Diggs WR | 0.00 |
| BN | Hunter Henry TE | 0.00 |
| BN | John Brown WR | 0.00 |
| BN | LeGarrette Blount RB | 0.40 |
| BN | Malcolm Brown RB | 1.50 |
| BN | New Orleans Saints DST | 11.00 |
| BN | Josh Rosen QB | 8.20 |
| BN | Sam Darnold QB | 0.00 |
| BN | JMon Moore WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Mitch Trubisky QB | 36.00 | 58.9% |
| RB | Isaiah Crowell RB | 10.70 | 98.3% |
| RB | Peyton Barber RB | 7.10 | |
| WR | Michael Thomas WR | 23.00 | 73.6% |
| WR | Corey Davis WR | 22.00 | |
| TE | Ed Dickson TE | 8.00 | 47.5% |
| FLEX | Josh Gordon WR | 10.10 | 81.1% |
| FLEX | Marquez Valdes-Scantling WR | 7.40 | |
| DST | Tennessee Titans DST | 8.00 | 100% |
| Total | 132.3 | 73.9% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 28.90 | 100% |
| RB | Todd Gurley RB | 23.50 | 100% |
| RB | Doug Martin RB | 10.70 | |
| WR | Keenan Allen WR | 14.70 | 69.6% |
| WR | Josh Doctson WR | 12.60 | |
| TE | Gerald Everett TE | 8.50 | 100% |
| FLEX | Elijah McGuire RB | 7.20 | 135.3% |
| FLEX | Cooper Kupp WR | 6.40 | |
| DST | New Orleans Saints DST | 11.00 | -63.6% |
| Total | 123.5 | 82.6% | |