| Starters | ||
| Pos | Player | Points |
| QB | Jared Goff QB | 35.10 |
| RB | Alvin Kamara RB | 17.95 |
| RB | Kareem Hunt RB | 18.60 |
| WR | Tyler Boyd WR | 9.10 |
| WR | JuJu Smith-Schuster WR | 14.40 |
| TE | Jimmy Graham TE | 1.80 |
| FLEX | Alex Collins RB | 7.80 |
| FLEX | Kerryon Johnson RB | 16.70 |
| DST | Denver Broncos DST | 2.00 |
| Total | 123.45 | |
| Starters | ||
| Pos | Player | Points |
| QB | Mitch Trubisky QB | 14.90 |
| RB | Peyton Barber RB | 18.00 |
| RB | Marlon Mack RB | 13.40 |
| WR | Alshon Jeffery WR | 5.30 |
| WR | Michael Thomas WR | 17.20 |
| TE | C.J. Uzomah TE | 5.60 |
| FLEX | Corey Davis WR | 3.90 |
| FLEX | Marquez Valdes-Scantling WR | 1.30 |
| DST | Washington Commanders DST | 10.00 |
| Total | 89.6 | |
| Bench | ||
| Pos | Player | Points |
| BN | A.J. Green WR | 0.00 |
| BN | Russell Wilson QB | 18.10 |
| BN | Philadelphia Eagles DST | -11.00 |
| BN | Devin Funchess TE | 4.90 |
| BN | Doug Baldwin WR | 14.70 |
| BN | DeSean Jackson WR | 5.80 |
| BN | Javorius Allen RB | 0.20 |
| BN | Charles Clay TE | 0.00 |
| BN | Mike Davis RB | 0.00 |
| BN | Jordan Wilkins RB | 9.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Andrew Luck QB | 23.90 |
| BN | Josh Gordon WR | 0.00 |
| BN | Jamison Crowder WR | 0.00 |
| BN | Isaiah Crowell RB | 0.00 |
| BN | Indianapolis Colts DST | 14.00 |
| BN | Ed Dickson TE | 8.00 |
| BN | Tennessee Titans DST | -4.00 |
| BN | Derrius Guice RB | 0.00 |
| BN | Ito Smith RB | 3.20 |
| BN | Chris Herndon IV TE | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 35.10 | 100% |
| RB | Kareem Hunt RB | 18.60 | 100% |
| RB | Alvin Kamara RB | 17.95 | |
| WR | Doug Baldwin WR | 14.70 | 80.8% |
| WR | JuJu Smith-Schuster WR | 14.40 | |
| TE | Devin Funchess TE | 4.90 | 36.7% |
| FLEX | Kerryon Johnson RB | 16.70 | 95% |
| FLEX | Tyler Boyd WR | 9.10 | |
| DST | Denver Broncos DST | 2.00 | 100% |
| Total | 133.45 | 92.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Andrew Luck QB | 23.90 | 62.3% |
| RB | Peyton Barber RB | 18.00 | 100% |
| RB | Marlon Mack RB | 13.40 | |
| WR | Michael Thomas WR | 17.20 | 100% |
| WR | Alshon Jeffery WR | 5.30 | |
| TE | Ed Dickson TE | 8.00 | 70% |
| FLEX | C.J. Uzomah TE | 5.60 | 54.7% |
| FLEX | Corey Davis WR | 3.90 | |
| DST | Indianapolis Colts DST | 14.00 | 71.4% |
| Total | 109.3 | 82% | |