| Starters | ||
| Pos | Player | Points |
| QB | Ben Roethlisberger QB | 20.70 |
| RB | Mark Ingram RB | 22.30 |
| RB | Tevin Coleman RB | 10.00 |
| WR | Amari Cooper WR | 5.10 |
| WR | D.J. Moore WR | 25.20 |
| TE | Eric Ebron TE | 0.00 |
| FLEX | Joe Mixon RB | 12.70 |
| FLEX | Chris Carson RB | 12.30 |
| DST | Los Angeles Chargers DST | 0.00 |
| Total | 108.3 | |
| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 30.50 |
| RB | Todd Gurley RB | 10.90 |
| RB | Doug Martin RB | 6.30 |
| WR | Stefon Diggs WR | 25.10 |
| WR | John Brown WR | 2.80 |
| TE | Gerald Everett TE | 18.40 |
| FLEX | Jordan Howard RB | 7.00 |
| FLEX | Keenan Allen WR | 19.50 |
| DST | New Orleans Saints DST | 15.00 |
| Total | 135.5 | |
| Bench | ||
| Pos | Player | Points |
| BN | Giovani Bernard RB | 4.50 |
| BN | Kyle Rudolph TE | 2.30 |
| BN | LeSean McCoy RB | 0.00 |
| BN | Dallas Cowboys DST | 4.00 |
| BN | Julian Edelman WR | 0.00 |
| BN | Kansas City Chiefs DST | 7.00 |
| BN | Deshaun Watson QB | 9.00 |
| BN | Corey Clement RB | 8.20 |
| BN | Chris Godwin WR | 6.50 |
| BN | Calvin Ridley WR | 5.20 |
| Bench | ||
| Pos | Player | Points |
| BN | Hunter Henry TE | 0.00 |
| BN | New York Jets DST | 0.00 |
| BN | Josh Doctson WR | 4.70 |
| BN | LeGarrette Blount RB | 0.10 |
| BN | Malcolm Brown RB | 1.50 |
| BN | Cooper Kupp WR | 0.00 |
| BN | Josh Rosen QB | 13.40 |
| BN | Sam Darnold QB | 0.00 |
| BN | JMon Moore WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Ben Roethlisberger QB | 20.70 | 100% |
| RB | Mark Ingram RB | 22.30 | 92.3% |
| RB | Joe Mixon RB | 12.70 | |
| WR | D.J. Moore WR | 25.20 | 92.1% |
| WR | David Moore WR | 7.70 | |
| TE | Mark Andrews TE | 2.40 | 0% |
| FLEX | Chris Carson RB | 12.30 | 112.1% |
| FLEX | Tevin Coleman RB | 10.00 | |
| DST | Kansas City Chiefs DST | 7.00 | 0% |
| Total | 120.3 | 90% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 30.50 | 100% |
| RB | Todd Gurley RB | 10.90 | 96.1% |
| RB | Jordan Howard RB | 7.00 | |
| WR | Stefon Diggs WR | 25.10 | 62.6% |
| WR | Keenan Allen WR | 19.50 | |
| TE | Gerald Everett TE | 18.40 | 100% |
| FLEX | Doug Martin RB | 6.30 | 230.4% |
| FLEX | Jordan Matthews TE | 5.20 | |
| DST | New Orleans Saints DST | 15.00 | 100% |
| Total | 137.9 | 98.3% | |