| Starters | ||
| Pos | Player | Points |
| QB | Cam Newton QB | 5.40 |
| RB | James White RB | 10.70 |
| RB | Austin Ekeler RB | 36.40 |
| WR | Julio Jones WR | 12.10 |
| WR | James Washington WR | 6.10 |
| TE | Travis Kelce TE | 10.30 |
| FLEX | Derrick Henry RB | 28.40 |
| FLEX | Rashard Higgins WR | 5.60 |
| DST | Green Bay Packers DST | 13.00 |
| Total | 128 | |
| Starters | ||
| Pos | Player | Points |
| QB | Deshaun Watson QB | 30.70 |
| RB | Joe Mixon RB | 2.70 |
| RB | Chris Carson RB | 21.00 |
| WR | Amari Cooper WR | 19.60 |
| WR | Keenan Allen WR | 22.30 |
| TE | Delanie Walker TE | 20.00 |
| FLEX | Julian Edelman WR | 13.40 |
| FLEX | Chris Godwin WR | 12.80 |
| DST | Dallas Cowboys DST | 1.00 |
| Total | 143.5 | |
| Bench | ||
| Pos | Player | Points |
| BN | Spencer Ware RB | |
| BN | Devontae Booker RB | |
| BN | Taylor Gabriel WR | 3.40 |
| BN | Derek Carr QB | 14.60 |
| BN | Adam Humphries WR | 1.00 |
| BN | Jamaal Williams RB | 2.50 |
| BN | Carolina Panthers DST | 4.00 |
| BN | Chase Edmonds RB | 0.50 |
| BN | Dallas Goedert TE | 2.60 |
| BN | Anthony Miller WR | |
| BN | Jace Sternberger TE | |
| BN | Ryquell Armstead RB | 0.70 |
| BN | Mecole Hardman WR | |
| BN | Darrell Henderson RB | |
| BN | Dare Ogunbowale RB | 5.30 |
| Bench | ||
| Pos | Player | Points |
| BN | Jay Ajayi RB | |
| BN | Jamison Crowder WR | 17.30 |
| BN | Cleveland Browns DST | 1.00 |
| BN | Will Fuller WR | 7.90 |
| BN | Eric Ebron TE | 1.30 |
| BN | Tevin Coleman RB | 6.60 |
| BN | Jordan Reed TE | |
| BN | Ben Roethlisberger QB | 9.70 |
| BN | Emmanuel Sanders WR | 17.10 |
| BN | Lamar Miller RB | |
| BN | Matthew Stafford QB | 27.60 |
| BN | Nyheim Hines RB | 3.70 |
| BN | Mark Andrews TE | 20.80 |
| BN | Michael Gallup WR | 19.30 |
| BN | Tony Pollard RB | 2.40 |
| BN | Deebo Samuel WR | 3.20 |
| BN | Hollywood Brown WR | 28.70 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Derek Carr QB | 14.60 | 37% |
| RB | Austin Ekeler RB | 36.40 | 72.7% |
| RB | Derrick Henry RB | 28.40 | |
| WR | Julio Jones WR | 12.10 | 100% |
| WR | James Washington WR | 6.10 | |
| TE | Travis Kelce TE | 10.30 | 100% |
| FLEX | James White RB | 10.70 | 208.6% |
| FLEX | Rashard Higgins WR | 5.60 | |
| DST | Green Bay Packers DST | 13.00 | 100% |
| Total | 137.2 | 93.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Deshaun Watson QB | 30.70 | 100% |
| RB | Chris Carson RB | 21.00 | 85.9% |
| RB | Tevin Coleman RB | 6.60 | |
| WR | Hollywood Brown WR | 28.70 | 82.2% |
| WR | Keenan Allen WR | 22.30 | |
| TE | Mark Andrews TE | 20.80 | 96.2% |
| FLEX | Delanie Walker TE | 20.00 | 66.2% |
| FLEX | Amari Cooper WR | 19.60 | |
| DST | Dallas Cowboys DST | 1.00 | 100% |
| Total | 170.7 | 84.1% | |