| Starters | ||
| Pos | Player | Points |
| QB | Carson Wentz QB | 25.00 |
| RB | Kenyan Drake RB | 3.70 |
| RB | Dalvin Cook RB | 25.00 |
| WR | Allen Robinson WR | 13.70 |
| WR | Mike Evans WR | 3.80 |
| TE | David Njoku TE | 11.70 |
| FLEX | Peyton Barber RB | 5.50 |
| FLEX | Royce Freeman RB | 6.60 |
| DST | New England Patriots DST | 7.00 |
| Total | 102 | |
| Starters | ||
| Pos | Player | Points |
| QB | Mitch Trubisky QB | 8.20 |
| RB | Jordan Howard RB | 6.50 |
| RB | Marlon Mack RB | 25.40 |
| WR | Tyler Lockett WR | 10.90 |
| WR | Sammy Watkins WR | 42.30 |
| TE | Tyler Eifert TE | 5.20 |
| FLEX | Michael Thomas WR | 17.30 |
| FLEX | Derrius Guice RB | 5.30 |
| DST | Indianapolis Colts DST | 4.00 |
| Total | 125.1 | |
| Bench | ||
| Pos | Player | Points |
| BN | Tom Brady QB | 25.60 |
| BN | Randall Cobb WR | 14.90 |
| BN | Dion Lewis RB | 2.80 |
| BN | Demaryius Thomas WR | |
| BN | Jesse James TE | 2.00 |
| BN | Frank Gore RB | 2.00 |
| BN | Adrian Peterson RB | |
| BN | Keelan Cole WR | |
| BN | Kyler Murray QB | 21.60 |
| BN | Irv Smith Jr. TE | |
| BN | NKeal Harry TE | |
| Bench | ||
| Pos | Player | Points |
| BN | Hayden Hurst TE | 5.60 |
| BN | Ito Smith RB | 4.50 |
| BN | Donte Moncrief WR | 2.20 |
| BN | Jimmy Garoppolo QB | 10.40 |
| BN | Isaiah Crowell RB | |
| BN | Greg Olsen TE | 5.60 |
| BN | Jacoby Brissett QB | 16.50 |
| BN | Corey Davis WR | |
| BN | Tennessee Titans DST | 22.00 |
| BN | Darren Waller TE | 10.50 |
| BN | Kalen Ballage RB | 1.70 |
| BN | Chris Herndon IV TE | |
| BN | Keke Coutee WR | |
| BN | Miles Boykin WR | 7.00 |
| BN | Noah Fant TE | 3.40 |
| BN | Damien Harris RB | |
| BN | Preston Williams WR | 9.90 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Tom Brady QB | 25.60 | 97.7% |
| RB | Dalvin Cook RB | 25.00 | 90.8% |
| RB | Royce Freeman RB | 6.60 | |
| WR | Randall Cobb WR | 14.90 | 61.2% |
| WR | Allen Robinson WR | 13.70 | |
| TE | David Njoku TE | 11.70 | 100% |
| FLEX | Peyton Barber RB | 5.50 | 130.1% |
| FLEX | Mike Evans WR | 3.80 | |
| DST | New England Patriots DST | 7.00 | 100% |
| Total | 113.8 | 89.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jacoby Brissett QB | 16.50 | 49.7% |
| RB | Marlon Mack RB | 25.40 | 100% |
| RB | Jordan Howard RB | 6.50 | |
| WR | Sammy Watkins WR | 42.30 | 89.3% |
| WR | Michael Thomas WR | 17.30 | |
| TE | Darren Waller TE | 10.50 | 49.5% |
| FLEX | Tyler Lockett WR | 10.90 | 108.7% |
| FLEX | Preston Williams WR | 9.90 | |
| DST | Tennessee Titans DST | 22.00 | 18.2% |
| Total | 161.3 | 77.6% | |