| Starters | ||
| Pos | Player | Points |
| QB | Carson Palmer QB | 15.60 |
| RB | Jerick McKinnon RB | 26.20 |
| RB | Latavius Murray RB | 5.30 |
| WR | Kelvin Benjamin WR | 13.80 |
| WR | Pierre Garcon WR | 13.40 |
| TE | Evan Engram TE | 0.00 |
| FLEX | Tyrell Williams WR | 2.70 |
| FLEX | Chris Hogan WR | 17.40 |
| DST | Pittsburgh Steelers DST | 4.00 |
| Total | 98.4 | |
| Starters | ||
| Pos | Player | Points |
| QB | Deshaun Watson QB | 35.50 |
| RB | LeSean McCoy RB | 11.90 |
| RB | Joe Mixon RB | 11.10 |
| WR | Antonio Brown WR | 20.70 |
| WR | Jordy Nelson WR | 9.40 |
| TE | Delanie Walker TE | 4.00 |
| FLEX | Martavis Bryant WR | 5.90 |
| FLEX | Michael Crabtree WR | 17.20 |
| DST | New York Jets DST | 5.00 |
| Total | 120.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | Marcus Mariota QB | 0.00 |
| BN | Arizona Cardinals DST | -1.00 |
| BN | Dion Lewis RB | 8.50 |
| BN | Charcandrick West RB | 14.30 |
| BN | Chris Johnson RB | 3.40 |
| BN | Trevor Siemian QB | 0.00 |
| BN | Kerwynn Williams RB | 3.90 |
| BN | J.J. Nelson WR | 9.40 |
| Bench | ||
| Pos | Player | Points |
| BN | Drew Brees QB | 0.00 |
| BN | Mark Ingram RB | 0.00 |
| BN | Wendell Smallwood RB | 0.00 |
| BN | C.J. Fiedorowicz TE | 0.00 |
| BN | Eli Manning QB | 13.00 |
| BN | Terrelle Pryor WR | 0.00 |
| BN | Washington Commanders DST | 0.00 |
| BN | Robby Anderson WR | 2.60 |
| BN | James Conner RB | 0.90 |
| BN | Benjamin Watson TE | 1.20 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Carson Palmer QB | 15.60 | 100% |
| RB | Jerick McKinnon RB | 26.20 | 77.8% |
| RB | Charcandrick West RB | 14.30 | |
| WR | Chris Hogan WR | 17.40 | 87.2% |
| WR | Kelvin Benjamin WR | 13.80 | |
| TE | Evan Engram TE | 0.00 | -- |
| FLEX | Pierre Garcon WR | 13.40 | 88.2% |
| FLEX | J.J. Nelson WR | 9.40 | |
| DST | Pittsburgh Steelers DST | 4.00 | 100% |
| Total | 114.1 | 86.2% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Deshaun Watson QB | 35.50 | 100% |
| RB | LeSean McCoy RB | 11.90 | 100% |
| RB | Joe Mixon RB | 11.10 | |
| WR | Antonio Brown WR | 20.70 | 79.4% |
| WR | Michael Crabtree WR | 17.20 | |
| TE | Delanie Walker TE | 4.00 | 100% |
| FLEX | Jordy Nelson WR | 9.40 | 151% |
| FLEX | Martavis Bryant WR | 5.90 | |
| DST | New York Jets DST | 5.00 | 100% |
| Total | 120.7 | 100% | |