| Starters | ||
| Pos | Player | Points |
| QB | Patrick Mahomes QB | 31.60 |
| RB | LeVeon Bell RB | 15.90 |
| RB | Tarik Cohen RB | 3.50 |
| WR | Odell Beckham WR | 25.10 |
| WR | Adam Thielen WR | 10.00 |
| TE | Jared Cook TE | 3.50 |
| FLEX | LeSean McCoy RB | 3.80 |
| FLEX | Devin Singletary RB | 11.70 |
| DST | Baltimore Ravens DST | 4.00 |
| Total | 109.1 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jacoby Brissett QB | 16.30 |
| RB | Jordan Howard RB | 3.10 |
| RB | Marlon Mack RB | 7.30 |
| WR | Tyler Lockett WR | 12.90 |
| WR | Sammy Watkins WR | 7.90 |
| TE | Darren Waller TE | 9.30 |
| FLEX | Michael Thomas WR | 13.90 |
| FLEX | Corey Davis WR | 5.30 |
| DST | Indianapolis Colts DST | 7.00 |
| Total | 83 | |
| Bench | ||
| Pos | Player | Points |
| BN | Quincy Enunwa WR | |
| BN | Kyle Rudolph TE | 2.40 |
| BN | Chris Thompson RB | 7.60 |
| BN | Tyreek Hill WR | |
| BN | Houston Texans DST | 11.00 |
| BN | Geronimo Allison WR | 8.50 |
| BN | DOnta Foreman RB | |
| BN | Kenny Stills WR | 4.80 |
| BN | Lamar Jackson QB | 30.90 |
| BN | Justice Hill RB | 1.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Jimmy Garoppolo QB | 22.60 |
| BN | Isaiah Crowell RB | |
| BN | Greg Olsen TE | 14.00 |
| BN | Tennessee Titans DST | 9.00 |
| BN | Raheem Mostert RB | 22.60 |
| BN | Kalen Ballage RB | 1.70 |
| BN | Chris Herndon IV TE | |
| BN | Keke Coutee WR | 1.70 |
| BN | Damien Harris RB | |
| BN | Preston Williams WR | 8.30 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Patrick Mahomes QB | 31.60 | 100% |
| RB | LeVeon Bell RB | 15.90 | 70.3% |
| RB | Devin Singletary RB | 11.70 | |
| WR | Odell Beckham WR | 25.10 | 100% |
| WR | Adam Thielen WR | 10.00 | |
| TE | Jared Cook TE | 3.50 | 100% |
| FLEX | Geronimo Allison WR | 8.50 | 96.3% |
| FLEX | Chris Thompson RB | 7.60 | |
| DST | Houston Texans DST | 11.00 | 36.4% |
| Total | 124.9 | 87.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 22.60 | 72.1% |
| RB | Raheem Mostert RB | 22.60 | 34.8% |
| RB | Marlon Mack RB | 7.30 | |
| WR | Michael Thomas WR | 13.90 | 77.6% |
| WR | Tyler Lockett WR | 12.90 | |
| TE | Greg Olsen TE | 14.00 | 66.4% |
| FLEX | Darren Waller TE | 9.30 | 108.5% |
| FLEX | Tyler Eifert TE | 8.40 | |
| DST | Tennessee Titans DST | 9.00 | 77.8% |
| Total | 120 | 69.2% | |