| Starters | ||
| Pos | Player | Points |
| QB | Deshaun Watson QB | 25.80 |
| RB | Joe Mixon RB | 16.40 |
| RB | Chris Carson RB | 3.50 |
| WR | Keenan Allen WR | 37.10 |
| WR | Hollywood Brown WR | 5.90 |
| TE | Mark Andrews TE | 3.00 |
| FLEX | Julian Edelman WR | 15.70 |
| FLEX | Chris Godwin WR | 5.50 |
| DST | Dallas Cowboys DST | 11.00 |
| Total | 123.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Matt Ryan QB | 22.50 |
| RB | Carlos Hyde RB | 7.90 |
| RB | Josh Jacobs RB | 4.40 |
| WR | Robert Woods WR | 7.30 |
| WR | JJ Arcega-Whiteside WR | 1.50 |
| TE | Austin Hooper TE | 21.60 |
| FLEX | Dede Westbrook WR | 7.50 |
| FLEX | DJ Chark Jr. WR | 15.60 |
| DST | Los Angeles Chargers DST | 3.00 |
| Total | 91.3 | |
| Bench | ||
| Pos | Player | Points |
| BN | Will Fuller WR | 7.60 |
| BN | Delanie Walker TE | 9.90 |
| BN | Tevin Coleman RB | |
| BN | Amari Cooper WR | 23.80 |
| BN | Emmanuel Sanders WR | 2.00 |
| BN | Matthew Stafford QB | 12.10 |
| BN | Ito Smith RB | |
| BN | Michael Gallup WR | |
| BN | Tony Pollard RB | 20.30 |
| BN | Deebo Samuel WR | 5.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Jacksonville Jaguars DST | 14.00 |
| BN | Jalen Richard RB | 4.40 |
| BN | Alshon Jeffery WR | |
| BN | O.J. Howard TE | 8.10 |
| BN | Damien Williams RB | |
| BN | Baker Mayfield QB | 9.70 |
| BN | Ian Thomas TE | |
| BN | TreQuan Smith WR | |
| BN | Deon Cain WR | 1.50 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Deshaun Watson QB | 25.80 | 100% |
| RB | Tony Pollard RB | 20.30 | 54.2% |
| RB | Joe Mixon RB | 16.40 | |
| WR | Keenan Allen WR | 37.10 | 70.6% |
| WR | Amari Cooper WR | 23.80 | |
| TE | Delanie Walker TE | 9.90 | 30.3% |
| FLEX | Julian Edelman WR | 15.70 | 91% |
| FLEX | Will Fuller WR | 7.60 | |
| DST | Dallas Cowboys DST | 11.00 | 100% |
| Total | 167.6 | 73.9% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Matt Ryan QB | 22.50 | 100% |
| RB | Carlos Hyde RB | 7.90 | 100% |
| RB | Jalen Richard RB | 4.40 | |
| WR | Paul Richardson WR | 18.30 | 26% |
| WR | DJ Chark Jr. WR | 15.60 | |
| TE | Austin Hooper TE | 21.60 | 100% |
| FLEX | O.J. Howard TE | 8.10 | 148.1% |
| FLEX | Dede Westbrook WR | 7.50 | |
| DST | Jacksonville Jaguars DST | 14.00 | 21.4% |
| Total | 119.9 | 76.1% | |