| Starters | ||
| Pos | Player | Points |
| QB | Jimmy Garoppolo QB | 9.40 |
| RB | Jordan Howard RB | 9.70 |
| RB | Marlon Mack RB | 15.80 |
| WR | Tyler Lockett WR | 26.90 |
| WR | Michael Thomas WR | 13.90 |
| TE | Darren Waller TE | 20.60 |
| FLEX | Sammy Watkins WR | 8.90 |
| FLEX | Raheem Mostert RB | 5.90 |
| DST | Tennessee Titans DST | 2.00 |
| Total | 113.1 | |
| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 41.30 |
| RB | Alvin Kamara RB | 32.60 |
| RB | Kerryon Johnson RB | 10.80 |
| WR | Tyler Boyd WR | 9.80 |
| WR | JuJu Smith-Schuster WR | 15.60 |
| TE | Jimmy Graham TE | |
| FLEX | Mike Davis RB | 0.20 |
| FLEX | Jordan Wilkins RB | -0.20 |
| DST | Philadelphia Eagles DST | 4.00 |
| Total | 114.1 | |
| Bench | ||
| Pos | Player | Points |
| BN | Greg Olsen TE | 22.50 |
| BN | Jacoby Brissett QB | 20.80 |
| BN | Indianapolis Colts DST | 1.00 |
| BN | Corey Davis WR | 5.90 |
| BN | Kalen Ballage RB | 3.20 |
| BN | Chris Herndon IV TE | |
| BN | Keke Coutee WR | |
| BN | Ty Johnson RB | 1.00 |
| BN | Damien Harris RB | |
| BN | Preston Williams WR | 8.80 |
| Bench | ||
| Pos | Player | Points |
| BN | Marqise Lee WR | |
| BN | Denver Broncos DST | 0.00 |
| BN | A.J. Green WR | |
| BN | Devin Funchess TE | |
| BN | Doug Baldwin WR | |
| BN | DeSean Jackson WR | |
| BN | Jared Goff QB | 14.10 |
| BN | Kareem Hunt RB | |
| BN | Jonnu Smith TE | 3.00 |
| BN | Dwayne Haskins QB | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jacoby Brissett QB | 20.80 | 45.2% |
| RB | Marlon Mack RB | 15.80 | 100% |
| RB | Jordan Howard RB | 9.70 | |
| WR | Tyler Lockett WR | 26.90 | 100% |
| WR | Michael Thomas WR | 13.90 | |
| TE | Greg Olsen TE | 22.50 | 91.6% |
| FLEX | Darren Waller TE | 20.60 | 50.2% |
| FLEX | Sammy Watkins WR | 8.90 | |
| DST | Tennessee Titans DST | 2.00 | 100% |
| Total | 141.1 | 80.2% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 41.30 | 100% |
| RB | Alvin Kamara RB | 32.60 | 100% |
| RB | Kerryon Johnson RB | 10.80 | |
| WR | JuJu Smith-Schuster WR | 15.60 | 100% |
| WR | Tyler Boyd WR | 9.80 | |
| TE | Jonnu Smith TE | 3.00 | 0% |
| FLEX | Mike Davis RB | 0.20 | 0% |
| FLEX | Jordan Wilkins RB | -0.20 | |
| DST | Philadelphia Eagles DST | 4.00 | 100% |
| Total | 117.1 | 97.4% | |