| Starters | ||
| Pos | Player | Points |
| QB | Cam Newton QB | 26.20 |
| RB | Mike Gillislee RB | 5.20 |
| RB | Todd Gurley RB | 4.00 |
| WR | Stefon Diggs WR | 0.90 |
| WR | Keenan Allen WR | 8.70 |
| TE | Hunter Henry TE | 11.70 |
| FLEX | Davante Adams WR | 22.10 |
| FLEX | Nelson Agholor WR | 17.30 |
| DST | New York Giants DST | 3.00 |
| Total | 99.1 | |
| Starters | ||
| Pos | Player | Points |
| QB | Alex Smith QB | 26.90 |
| RB | LeGarrette Blount RB | 7.40 |
| RB | Bilal Powell RB | 5.30 |
| WR | DeSean Jackson WR | 13.10 |
| WR | Golden Tate WR | 7.30 |
| TE | Jimmy Graham TE | 12.70 |
| FLEX | Frank Gore RB | 10.10 |
| FLEX | Jarvis Landry WR | 14.30 |
| DST | Detroit Lions DST | 2.00 |
| Total | 99.1 | |
| Bench | ||
| Pos | Player | Points |
| BN | Jeremy Hill RB | 1.60 |
| BN | C.J. Prosise RB | 0.00 |
| BN | Jalen Richard RB | 4.10 |
| BN | Jared Cook TE | 2.00 |
| BN | Sam Bradford QB | 1.40 |
| BN | Josh Doctson WR | 0.00 |
| BN | Chris Conley WR | 6.50 |
| BN | Orleans Darkwa RB | 13.70 |
| BN | Gerald Everett TE | 1.30 |
| BN | Cooper Kupp WR | 5.90 |
| Bench | ||
| Pos | Player | Points |
| BN | Julio Jones WR | 0.00 |
| BN | Taylor Gabriel WR | 0.00 |
| BN | Brandon Marshall WR | 2.50 |
| BN | Kirk Cousins QB | 0.00 |
| BN | Ty Montgomery RB | 0.00 |
| BN | Kenny Britt WR | 0.00 |
| BN | Kansas City Chiefs DST | 9.00 |
| BN | Shane Vereen RB | 7.50 |
| BN | Marshawn Lynch RB | 11.80 |
| BN | Samaje Perine RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Cam Newton QB | 26.20 | 100% |
| RB | Orleans Darkwa RB | 13.70 | 48.7% |
| RB | Mike Gillislee RB | 5.20 | |
| WR | Davante Adams WR | 22.10 | 24.4% |
| WR | Nelson Agholor WR | 17.30 | |
| TE | Hunter Henry TE | 11.70 | 100% |
| FLEX | Keenan Allen WR | 8.70 | 259.2% |
| FLEX | Chris Conley WR | 6.50 | |
| DST | New York Giants DST | 3.00 | 100% |
| Total | 114.4 | 86.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Alex Smith QB | 26.90 | 100% |
| RB | Marshawn Lynch RB | 11.80 | 58% |
| RB | Frank Gore RB | 10.10 | |
| WR | Jarvis Landry WR | 14.30 | 74.5% |
| WR | DeSean Jackson WR | 13.10 | |
| TE | Jimmy Graham TE | 12.70 | 100% |
| FLEX | Shane Vereen RB | 7.50 | 163.8% |
| FLEX | LeGarrette Blount RB | 7.40 | |
| DST | Kansas City Chiefs DST | 9.00 | 22.2% |
| Total | 112.8 | 87.9% | |