| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 14.30 |
| RB | Alvin Kamara RB | 10.40 |
| RB | Kerryon Johnson RB | 14.70 |
| WR | Tyler Boyd WR | 4.80 |
| WR | JuJu Smith-Schuster WR | 3.00 |
| TE | Jimmy Graham TE | 15.10 |
| FLEX | Mike Davis RB | 0.00 |
| FLEX | Jordan Wilkins RB | 3.30 |
| DST | Denver Broncos DST | 0.00 |
| Total | 65.6 | |
| Starters | ||
| Pos | Player | Points |
| QB | Derek Carr QB | 13.46 |
| RB | Jamaal Williams RB | 0.50 |
| RB | Austin Ekeler RB | 26.70 |
| WR | Julio Jones WR | 7.30 |
| WR | Mecole Hardman WR | 1.35 |
| TE | Travis Kelce TE | 12.00 |
| FLEX | James White RB | 9.80 |
| FLEX | Derrick Henry RB | 11.30 |
| DST | Green Bay Packers DST | -1.00 |
| Total | 81.41 | |
| Bench | ||
| Pos | Player | Points |
| BN | Marqise Lee WR | 1.00 |
| BN | A.J. Green WR | 0.00 |
| BN | Philadelphia Eagles DST | 0.00 |
| BN | DeSean Jackson WR | 0.00 |
| BN | Javorius Allen RB | 0.00 |
| BN | Jared Goff QB | 20.68 |
| BN | Kareem Hunt RB | 0.00 |
| BN | Jonnu Smith TE | 1.00 |
| BN | Dwayne Haskins QB | 0.58 |
| Bench | ||
| Pos | Player | Points |
| BN | Cam Newton QB | 0.00 |
| BN | Taylor Gabriel WR | 0.00 |
| BN | Rashard Higgins WR | 0.00 |
| BN | Adam Humphries WR | 2.60 |
| BN | Carolina Panthers DST | 15.00 |
| BN | Chase Edmonds RB | 3.70 |
| BN | Dallas Goedert TE | 8.60 |
| BN | Anthony Miller WR | 2.10 |
| BN | James Washington WR | 0.00 |
| BN | Darrell Henderson RB | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 20.68 | 69.1% |
| RB | Kerryon Johnson RB | 14.70 | 100% |
| RB | Alvin Kamara RB | 10.40 | |
| WR | Tyler Boyd WR | 4.80 | 100% |
| WR | JuJu Smith-Schuster WR | 3.00 | |
| TE | Jimmy Graham TE | 15.10 | 100% |
| FLEX | Jordan Wilkins RB | 3.30 | 57.9% |
| FLEX | Ameer Abdullah RB | 2.40 | |
| DST | Philadelphia Eagles DST | 0.00 | -- |
| Total | 74.38 | 88.2% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Derek Carr QB | 13.46 | 100% |
| RB | Austin Ekeler RB | 26.70 | 71.4% |
| RB | Ryquell Armstead RB | 11.40 | |
| WR | Julio Jones WR | 7.30 | 87.4% |
| WR | Adam Humphries WR | 2.60 | |
| TE | Travis Kelce TE | 12.00 | 100% |
| FLEX | Derrick Henry RB | 11.30 | 100% |
| FLEX | James White RB | 9.80 | |
| DST | Carolina Panthers DST | 15.00 | -6.7% |
| Total | 109.56 | 74.3% | |