| Starters | ||
| Pos | Player | Points |
| QB | Gardner Minshew QB | 21.16 |
| RB | James White RB | 10.20 |
| RB | Derrick Henry RB | 13.80 |
| WR | Julio Jones WR | 5.70 |
| WR | Mecole Hardman WR | 10.40 |
| TE | Travis Kelce TE | 9.00 |
| FLEX | Cole Beasley WR | 3.60 |
| FLEX | Austin Ekeler RB | 14.80 |
| DST | Carolina Panthers DST | 8.00 |
| Total | 96.66 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jacoby Brissett QB | 10.94 |
| RB | Jordan Howard RB | 12.20 |
| RB | Marlon Mack RB | 16.30 |
| WR | Tyler Lockett WR | 13.95 |
| WR | Michael Thomas WR | 35.70 |
| TE | Darren Waller TE | 5.90 |
| FLEX | Sammy Watkins WR | 0.00 |
| FLEX | Greg Olsen TE | 0.00 |
| DST | Tennessee Titans DST | 7.00 |
| Total | 101.99 | |
| Bench | ||
| Pos | Player | Points |
| BN | Taylor Gabriel WR | 0.00 |
| BN | Derek Carr QB | 7.96 |
| BN | Green Bay Packers DST | 2.00 |
| BN | Adam Humphries WR | 5.10 |
| BN | Jamaal Williams RB | 0.00 |
| BN | Chase Edmonds RB | 16.10 |
| BN | Dallas Goedert TE | 1.60 |
| BN | Anthony Miller WR | 7.20 |
| BN | James Washington WR | 6.70 |
| BN | Darrell Henderson RB | 0.00 |
| Bench | ||
| Pos | Player | Points |
| BN | Jimmy Garoppolo QB | 14.94 |
| BN | Indianapolis Colts DST | 9.00 |
| BN | Phillip Dorsett WR | 0.00 |
| BN | Corey Davis WR | 3.80 |
| BN | Raheem Mostert RB | 3.40 |
| BN | Chris Herndon IV TE | 0.00 |
| BN | Keke Coutee WR | 8.70 |
| BN | Ty Johnson RB | 0.00 |
| BN | Noah Fant TE | 1.10 |
| BN | Damien Harris RB | 0.00 |
| BN | Preston Williams WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Gardner Minshew QB | 21.16 | 100% |
| RB | Chase Edmonds RB | 16.10 | 77.7% |
| RB | Austin Ekeler RB | 14.80 | |
| WR | Mecole Hardman WR | 10.40 | 91.5% |
| WR | Anthony Miller WR | 7.20 | |
| TE | Travis Kelce TE | 9.00 | 100% |
| FLEX | Derrick Henry RB | 13.80 | 76.7% |
| FLEX | James White RB | 10.20 | |
| DST | Carolina Panthers DST | 8.00 | 100% |
| Total | 110.66 | 87.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 14.94 | 73.2% |
| RB | Marlon Mack RB | 16.30 | 100% |
| RB | Jordan Howard RB | 12.20 | |
| WR | Michael Thomas WR | 35.70 | 100% |
| WR | Tyler Lockett WR | 13.95 | |
| TE | Darren Waller TE | 5.90 | 100% |
| FLEX | Keke Coutee WR | 8.70 | 0% |
| FLEX | Nyheim Hines RB | 6.50 | |
| DST | Indianapolis Colts DST | 9.00 | 77.8% |
| Total | 123.19 | 82.8% | |