| Starters | ||
| Pos | Player | Points |
| QB | Jimmy Garoppolo QB | 12.10 |
| RB | Jordan Howard RB | 4.90 |
| RB | Duke Johnson RB | 12.40 |
| WR | Tyler Lockett WR | 10.30 |
| WR | Michael Thomas WR | 12.90 |
| TE | Greg Olsen TE | 7.20 |
| FLEX | Corey Davis WR | 5.10 |
| FLEX | Preston Williams WR | 4.10 |
| DST | Tennessee Titans DST | 6.00 |
| Total | 75 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jameis Winston QB | 12.10 |
| RB | David Johnson RB | 25.20 |
| RB | Christian McCaffrey RB | 19.70 |
| WR | Brandin Cooks WR | 4.70 |
| WR | Marvin Jones WR | 2.70 |
| TE | Zach Ertz TE | 5.40 |
| FLEX | James Conner RB | 27.40 |
| FLEX | Aaron Jones RB | 6.00 |
| DST | Seattle Seahawks DST | 6.00 |
| Total | 109.2 | |
| Bench | ||
| Pos | Player | Points |
| BN | Sammy Watkins WR | |
| BN | Jacoby Brissett QB | |
| BN | Indianapolis Colts DST | 0.00 |
| BN | Marlon Mack RB | |
| BN | Darren Waller TE | |
| BN | Raheem Mostert RB | 1.30 |
| BN | Chris Herndon IV TE | |
| BN | Keke Coutee WR | 5.90 |
| BN | Noah Fant TE | 2.60 |
| BN | Damien Harris RB | |
| Bench | ||
| Pos | Player | Points |
| BN | Pittsburgh Steelers DST | 14.00 |
| BN | T.Y. Hilton WR | |
| BN | Jack Doyle TE | |
| BN | Davante Adams WR | |
| BN | Jamison Crowder WR | 12.80 |
| BN | Miami Dolphins DST | 1.00 |
| BN | Robby Anderson WR | 21.00 |
| BN | Josh Allen QB | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 12.10 | 100% |
| RB | Duke Johnson RB | 12.40 | 100% |
| RB | Jordan Howard RB | 4.90 | |
| WR | Michael Thomas WR | 12.90 | 100% |
| WR | Tyler Lockett WR | 10.30 | |
| TE | Greg Olsen TE | 7.20 | 100% |
| FLEX | Keke Coutee WR | 5.90 | 83.6% |
| FLEX | Corey Davis WR | 5.10 | |
| DST | Tennessee Titans DST | 6.00 | 100% |
| Total | 76.8 | 97.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jameis Winston QB | 12.10 | 100% |
| RB | James Conner RB | 27.40 | 85.4% |
| RB | David Johnson RB | 25.20 | |
| WR | Robby Anderson WR | 21.00 | 21.9% |
| WR | Jamison Crowder WR | 12.80 | |
| TE | Zach Ertz TE | 5.40 | 100% |
| FLEX | Christian McCaffrey RB | 19.70 | 114.8% |
| FLEX | Benny Snell Jr. RB | 9.40 | |
| DST | Pittsburgh Steelers DST | 14.00 | 42.9% |
| Total | 147 | 74.3% | |