| Starters | ||
| Pos | Player | Points |
| QB | Drew Brees QB | 24.90 |
| RB | Todd Gurley RB | 10.40 |
| RB | Devonta Freeman RB | 12.20 |
| WR | Stefon Diggs WR | 15.80 |
| WR | Cooper Kupp WR | 31.50 |
| TE | Gerald Everett TE | 2.50 |
| FLEX | John Brown WR | 7.90 |
| FLEX | Calvin Ridley WR | 11.00 |
| DST | New Orleans Saints DST | 9.00 |
| Total | 125.2 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jimmy Garoppolo QB | 13.00 |
| RB | Marlon Mack RB | 15.50 |
| RB | Ty Johnson RB | 4.30 |
| WR | Tyler Lockett WR | 13.00 |
| WR | Michael Thomas WR | 21.80 |
| TE | Darren Waller TE | 8.10 |
| FLEX | Jordan Howard RB | 17.60 |
| FLEX | Corey Davis WR | 1.90 |
| DST | Indianapolis Colts DST | 8.00 |
| Total | 103.2 | |
| Bench | ||
| Pos | Player | Points |
| BN | Carson Wentz QB | 14.40 |
| BN | Malcolm Brown RB | |
| BN | Cleveland Browns DST | 5.00 |
| BN | Sam Darnold QB | 12.60 |
| BN | Ronald Jones II RB | 5.70 |
| BN | D.J. Moore WR | 6.30 |
| BN | Dante Pettis WR | 1.00 |
| BN | Keesean Johnson WR | |
| BN | Jakobi Meyers WR | 1.00 |
| BN | Miles Sanders RB | 21.30 |
| Bench | ||
| Pos | Player | Points |
| BN | Sammy Watkins WR | 7.00 |
| BN | Duke Johnson RB | 11.40 |
| BN | Greg Olsen TE | 2.30 |
| BN | Jacoby Brissett QB | 9.50 |
| BN | Phillip Dorsett WR | 5.80 |
| BN | Tennessee Titans DST | 10.00 |
| BN | Chris Herndon IV TE | |
| BN | Keke Coutee WR | |
| BN | Damien Harris RB | |
| BN | Preston Williams WR | 6.20 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Drew Brees QB | 24.90 | 100% |
| RB | Miles Sanders RB | 21.30 | 67.5% |
| RB | Devonta Freeman RB | 12.20 | |
| WR | Cooper Kupp WR | 31.50 | 100% |
| WR | Stefon Diggs WR | 15.80 | |
| TE | Gerald Everett TE | 2.50 | 100% |
| FLEX | Calvin Ridley WR | 11.00 | 88.3% |
| FLEX | Todd Gurley RB | 10.40 | |
| DST | New Orleans Saints DST | 9.00 | 100% |
| Total | 138.6 | 90.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 13.00 | 100% |
| RB | Jordan Howard RB | 17.60 | 59.8% |
| RB | Marlon Mack RB | 15.50 | |
| WR | Michael Thomas WR | 21.80 | 100% |
| WR | Tyler Lockett WR | 13.00 | |
| TE | Darren Waller TE | 8.10 | 100% |
| FLEX | Raheem Mostert RB | 12.00 | 83.3% |
| FLEX | Duke Johnson RB | 11.40 | |
| DST | Tennessee Titans DST | 10.00 | 80% |
| Total | 122.4 | 84.3% | |