| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 10.00 |
| RB | Melvin Gordon RB | 10.40 |
| RB | Matt Breida RB | 5.50 |
| WR | Mohamed Sanu WR | 3.30 |
| WR | Curtis Samuel WR | 6.60 |
| TE | Vance McDonald TE | 3.40 |
| FLEX | Rex Burkhead RB | 1.80 |
| FLEX | Danny Amendola WR | 13.50 |
| DST | Minnesota Vikings DST | 13.00 |
| Total | 67.5 | |
| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 15.70 |
| RB | Alvin Kamara RB | |
| RB | Jordan Wilkins RB | 0.50 |
| WR | Tyler Boyd WR | 9.80 |
| WR | JuJu Smith-Schuster WR | 18.80 |
| TE | Jimmy Graham TE | 3.50 |
| FLEX | DeSean Jackson WR | |
| FLEX | Jonnu Smith TE | 16.80 |
| DST | Philadelphia Eagles DST | 13.00 |
| Total | 78.1 | |
| Bench | ||
| Pos | Player | Points |
| BN | Josh Gordon WR | |
| BN | Antonio Brown WR | |
| BN | Dak Prescott QB | |
| BN | Ezekiel Elliott RB | |
| BN | Nelson Agholor WR | 3.40 |
| BN | Jason Witten TE | |
| BN | Buffalo Bills DST | 3.00 |
| BN | Marquise Goodwin WR | |
| BN | Demarcus Robinson WR | 1.60 |
| BN | Zach Pascal WR | 1.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Marqise Lee WR | 1.30 |
| BN | Denver Broncos DST | 7.00 |
| BN | A.J. Green WR | |
| BN | Javorius Allen RB | |
| BN | Mike Davis RB | 1.30 |
| BN | Jared Goff QB | 22.90 |
| BN | Kareem Hunt RB | |
| BN | Kerryon Johnson RB | |
| BN | Dwayne Haskins QB | -0.70 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 10.00 | 100% |
| RB | Melvin Gordon RB | 10.40 | 100% |
| RB | Giovani Bernard RB | 5.50 | |
| WR | Josh Reynolds WR | 14.70 | 35.1% |
| WR | Danny Amendola WR | 13.50 | |
| TE | Vance McDonald TE | 3.40 | 100% |
| FLEX | Albert Wilson WR | 7.00 | 112.5% |
| FLEX | Curtis Samuel WR | 6.60 | |
| DST | Minnesota Vikings DST | 13.00 | 100% |
| Total | 84.1 | 80.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jared Goff QB | 22.90 | 68.6% |
| RB | Mike Davis RB | 1.30 | 27.8% |
| RB | Jordan Wilkins RB | 0.50 | |
| WR | JuJu Smith-Schuster WR | 18.80 | 100% |
| WR | Tyler Boyd WR | 9.80 | |
| TE | Jonnu Smith TE | 16.80 | 20.8% |
| FLEX | Jimmy Graham TE | 3.50 | 350% |
| FLEX | Marqise Lee WR | 1.30 | |
| DST | Philadelphia Eagles DST | 13.00 | 100% |
| Total | 87.9 | 88.9% | |