| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 20.80 |
| RB | Carlos Hyde RB | 2.30 |
| RB | Jordan Howard RB | 7.60 |
| WR | Odell Beckham WR | 20.00 |
| WR | Tyler Lockett WR | 5.30 |
| TE | Travis Kelce TE | 13.80 |
| FLEX | Theo Riddick RB | 7.30 |
| FLEX | Donte Moncrief WR | 4.70 |
| DST | Los Angeles Rams DST | 10.00 |
| Total | 91.8 | |
| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 11.50 |
| RB | Kareem Hunt RB | 13.10 |
| RB | Tarik Cohen RB | 3.20 |
| WR | A.J. Green WR | 26.40 |
| WR | Doug Baldwin WR | 5.70 |
| TE | Charles Clay TE | 4.10 |
| FLEX | Sterling Shepard WR | 1.40 |
| FLEX | Alex Collins RB | 5.50 |
| DST | San Francisco 49ers DST | 3.00 |
| Total | 73.9 | |
| Bench | ||
| Pos | Player | Points |
| BN | David Johnson RB | 0.00 |
| BN | Derrick Henry RB | 0.90 |
| BN | Terrance West RB | 1.70 |
| BN | Devontae Booker RB | 0.00 |
| BN | Jordan Matthews TE | 0.00 |
| BN | Willie Snead WR | 0.00 |
| BN | Cameron Brate TE | 15.30 |
| BN | Philadelphia Eagles DST | 7.00 |
| BN | DeAngelo Henderson RB | 0.00 |
| BN | Jay Cutler QB | 6.50 |
| Bench | ||
| Pos | Player | Points |
| BN | Tyrod Taylor QB | 8.90 |
| BN | Thomas Rawls RB | 4.50 |
| BN | Alvin Kamara RB | 0.00 |
| BN | Giovani Bernard RB | 4.20 |
| BN | Jermaine Kearse WR | 11.80 |
| BN | Jordan Reed TE | 0.00 |
| BN | Atlanta Falcons DST | 0.00 |
| BN | Branden Oliver RB | 0.00 |
| BN | Jared Goff QB | 7.70 |
| BN | Bennie Fowler WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 20.80 | 100% |
| RB | Jordan Howard RB | 7.60 | 66.4% |
| RB | Theo Riddick RB | 7.30 | |
| WR | Odell Beckham WR | 20.00 | 100% |
| WR | Tyler Lockett WR | 5.30 | |
| TE | Cameron Brate TE | 15.30 | 90.2% |
| FLEX | Travis Kelce TE | 13.80 | 64.9% |
| FLEX | Donte Moncrief WR | 4.70 | |
| DST | Los Angeles Rams DST | 10.00 | 100% |
| Total | 104.8 | 87.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 11.50 | 100% |
| RB | Kareem Hunt RB | 13.10 | 87.6% |
| RB | Alex Collins RB | 5.50 | |
| WR | A.J. Green WR | 26.40 | 84% |
| WR | Jermaine Kearse WR | 11.80 | |
| TE | Charles Clay TE | 4.10 | 100% |
| FLEX | Doug Baldwin WR | 5.70 | 67.6% |
| FLEX | Thomas Rawls RB | 4.50 | |
| DST | San Francisco 49ers DST | 3.00 | 100% |
| Total | 85.6 | 86.3% | |