| Starters | ||
| Pos | Player | Points |
| QB | Russell Wilson QB | 16.60 |
| RB | Alvin Kamara RB | 11.40 |
| RB | Kareem Hunt RB | 10.90 |
| WR | Tyler Boyd WR | 9.20 |
| WR | JuJu Smith-Schuster WR | 5.90 |
| TE | Jimmy Graham TE | 6.90 |
| FLEX | Jonnu Smith TE | 5.00 |
| FLEX | Jordan Wilkins RB | 2.00 |
| DST | Philadelphia Eagles DST | 0.00 |
| Total | 67.9 | |
| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 26.80 |
| RB | Kenyan Drake RB | 7.10 |
| RB | Dalvin Cook RB | 27.80 |
| WR | Allen Robinson WR | 11.60 |
| WR | Mike Evans WR | 10.20 |
| TE | Hunter Henry TE | 11.00 |
| FLEX | Randall Cobb WR | 19.60 |
| FLEX | Auden Tate WR | 5.10 |
| DST | New England Patriots DST | 0.00 |
| Total | 119.2 | |
| Bench | ||
| Pos | Player | Points |
| BN | Marqise Lee WR | |
| BN | Denver Broncos DST | 0.00 |
| BN | A.J. Green WR | |
| BN | Carlos Hyde RB | |
| BN | DeSean Jackson WR | |
| BN | Javorius Allen RB | |
| BN | Mike Davis RB | |
| BN | Jared Goff QB | 3.70 |
| BN | Kerryon Johnson RB | |
| BN | Dwayne Haskins QB | |
| Bench | ||
| Pos | Player | Points |
| BN | Peyton Barber RB | 11.20 |
| BN | Tom Brady QB | |
| BN | Frank Gore RB | 2.10 |
| BN | Adrian Peterson RB | |
| BN | David Njoku TE | |
| BN | Matt Breida RB | 3.50 |
| BN | Royce Freeman RB | |
| BN | Hayden Hurst TE | 3.00 |
| BN | Marquez Valdes-Scantling WR | |
| BN | NKeal Harry TE | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Russell Wilson QB | 16.60 | 100% |
| RB | Alvin Kamara RB | 11.40 | 100% |
| RB | Kareem Hunt RB | 10.90 | |
| WR | Tyler Boyd WR | 9.20 | 100% |
| WR | JuJu Smith-Schuster WR | 5.90 | |
| TE | Jimmy Graham TE | 6.90 | 100% |
| FLEX | Jonnu Smith TE | 5.00 | 100% |
| FLEX | Jordan Wilkins RB | 2.00 | |
| DST | Denver Broncos DST | 0.00 | -- |
| Total | 67.9 | 100% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Kyler Murray QB | 26.80 | 100% |
| RB | Dalvin Cook RB | 27.80 | 89.5% |
| RB | Peyton Barber RB | 11.20 | |
| WR | Randall Cobb WR | 19.60 | 69.9% |
| WR | Allen Robinson WR | 11.60 | |
| TE | Hunter Henry TE | 11.00 | 100% |
| FLEX | Demaryius Thomas WR | 11.40 | 114.4% |
| FLEX | Mike Evans WR | 10.20 | |
| DST | New England Patriots DST | 0.00 | -- |
| Total | 129.6 | 92% | |