| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 10.30 |
| RB | Ezekiel Elliott RB | 7.30 |
| RB | Melvin Gordon RB | 19.80 |
| WR | Curtis Samuel WR | 11.50 |
| WR | Zach Pascal WR | 3.60 |
| TE | Jason Witten TE | 2.70 |
| FLEX | Danny Amendola WR | 4.90 |
| FLEX | Josh Reynolds WR | 6.40 |
| DST | Buffalo Bills DST | 3.00 |
| Total | 69.5 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jimmy Garoppolo QB | 10.00 |
| RB | Marlon Mack RB | 8.70 |
| RB | Ty Johnson RB | 2.40 |
| WR | Tyler Lockett WR | 4.40 |
| WR | Sammy Watkins WR | 7.60 |
| TE | Darren Waller TE | 5.50 |
| FLEX | Michael Thomas WR | 21.70 |
| FLEX | Greg Olsen TE | 13.80 |
| DST | Indianapolis Colts DST | 10.00 |
| Total | 84.1 | |
| Bench | ||
| Pos | Player | Points |
| BN | Josh Gordon WR | 3.70 |
| BN | Antonio Brown WR | |
| BN | Dak Prescott QB | 25.90 |
| BN | Minnesota Vikings DST | 0.00 |
| BN | Rex Burkhead RB | |
| BN | Mohamed Sanu WR | |
| BN | Vance McDonald TE | 2.80 |
| BN | Tony Pollard RB | -0.40 |
| BN | Darius Slayton WR | 29.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Jordan Howard RB | |
| BN | Duke Johnson RB | |
| BN | Jacoby Brissett QB | |
| BN | Phillip Dorsett WR | |
| BN | Corey Davis WR | |
| BN | Tennessee Titans DST | 5.00 |
| BN | Chris Herndon IV TE | 1.20 |
| BN | Keke Coutee WR | |
| BN | Noah Fant TE | |
| BN | Damien Harris RB | |
| BN | Preston Williams WR | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Dak Prescott QB | 25.90 | 39.8% |
| RB | Melvin Gordon RB | 19.80 | 100% |
| RB | Ezekiel Elliott RB | 7.30 | |
| WR | Darius Slayton WR | 29.10 | 37.2% |
| WR | Curtis Samuel WR | 11.50 | |
| TE | Vance McDonald TE | 2.80 | 96.4% |
| FLEX | Demarcus Robinson WR | 7.60 | 80.7% |
| FLEX | Josh Reynolds WR | 6.40 | |
| DST | Buffalo Bills DST | 3.00 | 100% |
| Total | 113.4 | 61.3% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 10.00 | 100% |
| RB | Marlon Mack RB | 8.70 | 73.5% |
| RB | Nyheim Hines RB | 6.40 | |
| WR | Michael Thomas WR | 21.70 | 41% |
| WR | Sammy Watkins WR | 7.60 | |
| TE | Greg Olsen TE | 13.80 | 39.9% |
| FLEX | Darren Waller TE | 5.50 | 358.6% |
| FLEX | Tyler Lockett WR | 4.40 | |
| DST | Indianapolis Colts DST | 10.00 | 100% |
| Total | 88.1 | 95.5% | |