| Starters | ||
| Pos | Player | Points |
| QB | Jared Goff QB | 5.20 |
| RB | Carlos Hyde RB | 12.50 |
| RB | Alvin Kamara RB | 17.20 |
| WR | Tyler Boyd WR | 1.50 |
| WR | JuJu Smith-Schuster WR | 3.10 |
| TE | Jimmy Graham TE | |
| FLEX | Mike Davis RB | |
| FLEX | Jordan Wilkins RB | |
| DST | Denver Broncos DST | 9.00 |
| Total | 48.5 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jacoby Brissett QB | 15.10 |
| RB | Marlon Mack RB | 16.90 |
| RB | Ty Johnson RB | 1.10 |
| WR | Michael Thomas WR | 21.40 |
| WR | Sammy Watkins WR | 3.60 |
| TE | Darren Waller TE | 10.10 |
| FLEX | Duke Johnson RB | 5.40 |
| FLEX | Kareem Hunt RB | 8.80 |
| DST | Indianapolis Colts DST | 9.00 |
| Total | 91.4 | |
| Bench | ||
| Pos | Player | Points |
| BN | Marqise Lee WR | |
| BN | A.J. Green WR | |
| BN | Russell Wilson QB | |
| BN | Philadelphia Eagles DST | 4.00 |
| BN | DeSean Jackson WR | |
| BN | Javorius Allen RB | |
| BN | Jonnu Smith TE | |
| BN | Kerryon Johnson RB | |
| BN | Dwayne Haskins QB | 17.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Jordan Howard RB | |
| BN | Tyler Lockett WR | |
| BN | Jimmy Garoppolo QB | 29.70 |
| BN | Greg Olsen TE | 8.20 |
| BN | Corey Davis WR | |
| BN | Tennessee Titans DST | 0.00 |
| BN | Raheem Mostert RB | 3.70 |
| BN | Noah Fant TE | 7.30 |
| BN | Damien Harris RB | |
| BN | Preston Williams WR | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Dwayne Haskins QB | 17.10 | 30.4% |
| RB | Alvin Kamara RB | 17.20 | 100% |
| RB | Carlos Hyde RB | 12.50 | |
| WR | JuJu Smith-Schuster WR | 3.10 | 100% |
| WR | Tyler Boyd WR | 1.50 | |
| TE | Jonnu Smith TE | -- | |
| FLEX | Ameer Abdullah RB | 0.60 | 0% |
| FLEX | A.J. Green WR | ||
| DST | Denver Broncos DST | 9.00 | 100% |
| Total | 61 | 79.5% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 29.70 | 50.8% |
| RB | Marlon Mack RB | 16.90 | 59.4% |
| RB | Derrius Guice RB | 13.40 | |
| WR | Michael Thomas WR | 21.40 | 77.6% |
| WR | Phillip Dorsett WR | 10.80 | |
| TE | Darren Waller TE | 10.10 | 100% |
| FLEX | Nyheim Hines RB | 11.00 | 71.7% |
| FLEX | Kareem Hunt RB | 8.80 | |
| DST | Indianapolis Colts DST | 9.00 | 100% |
| Total | 131.1 | 69.7% | |