| Starters | ||
| Pos | Player | Points |
| QB | Jacoby Brissett QB | 13.20 |
| RB | Duke Johnson RB | 3.50 |
| RB | Kareem Hunt RB | 11.60 |
| WR | Tyler Lockett WR | 4.30 |
| WR | Michael Thomas WR | 21.10 |
| TE | Darren Waller TE | 5.60 |
| FLEX | Corey Davis WR | 3.90 |
| FLEX | Ty Johnson RB | 3.10 |
| DST | Tennessee Titans DST | 4.00 |
| Total | 70.3 | |
| Starters | ||
| Pos | Player | Points |
| QB | Carson Wentz QB | 8.90 |
| RB | Todd Gurley RB | 3.40 |
| RB | Miles Sanders RB | 10.10 |
| WR | Cooper Kupp WR | 6.50 |
| WR | D.J. Moore WR | 28.40 |
| TE | Gerald Everett TE | 3.30 |
| FLEX | Ronald Jones II RB | 14.20 |
| FLEX | Calvin Ridley WR | 19.00 |
| DST | Cleveland Browns DST | 10.00 |
| Total | 103.8 | |
| Bench | ||
| Pos | Player | Points |
| BN | Jordan Howard RB | |
| BN | Jimmy Garoppolo QB | 18.20 |
| BN | Sammy Watkins WR | |
| BN | Greg Olsen TE | 6.90 |
| BN | Indianapolis Colts DST | 2.00 |
| BN | Marlon Mack RB | |
| BN | Raheem Mostert RB | 13.20 |
| BN | Noah Fant TE | 2.90 |
| BN | Damien Harris RB | |
| BN | Preston Williams WR | |
| Bench | ||
| Pos | Player | Points |
| BN | Stefon Diggs WR | |
| BN | John Brown WR | 10.90 |
| BN | Devonta Freeman RB | |
| BN | Darren Fells TE | 2.90 |
| BN | New Orleans Saints DST | 4.00 |
| BN | Sam Darnold QB | 28.20 |
| BN | Dante Pettis WR | |
| BN | Keesean Johnson WR | |
| BN | Jakobi Meyers WR | 9.40 |
| BN | Andy Isabella WR | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 18.20 | 72.5% |
| RB | Raheem Mostert RB | 13.20 | 60.9% |
| RB | Kareem Hunt RB | 11.60 | |
| WR | Michael Thomas WR | 21.10 | 92.4% |
| WR | Miles Boykin WR | 6.40 | |
| TE | Greg Olsen TE | 6.90 | 81.2% |
| FLEX | Nyheim Hines RB | 7.10 | 55.1% |
| FLEX | Darren Waller TE | 5.60 | |
| DST | Tennessee Titans DST | 4.00 | 100% |
| Total | 94.1 | 74.7% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Sam Darnold QB | 28.20 | 31.6% |
| RB | Ronald Jones II RB | 14.20 | 55.6% |
| RB | Miles Sanders RB | 10.10 | |
| WR | D.J. Moore WR | 28.40 | 73.6% |
| WR | Calvin Ridley WR | 19.00 | |
| TE | Gerald Everett TE | 3.30 | 100% |
| FLEX | John Brown WR | 10.90 | 163.5% |
| FLEX | Jakobi Meyers WR | 9.40 | |
| DST | Cleveland Browns DST | 10.00 | 100% |
| Total | 133.5 | 77.8% | |