| Starters | ||
| Pos | Player | Points |
| QB | Tom Brady QB | 16.20 |
| RB | Melvin Gordon RB | 31.50 |
| RB | Tevin Coleman RB | 10.10 |
| WR | T.Y. Hilton WR | 2.40 |
| WR | Rishard Matthews WR | 8.90 |
| TE | Kyle Rudolph TE | 7.20 |
| FLEX | James White RB | 6.50 |
| FLEX | Andre Ellington RB | 0.00 |
| DST | Jacksonville Jaguars DST | 7.00 |
| Total | 89.8 | |
| Starters | ||
| Pos | Player | Points |
| QB | Philip Rivers QB | 14.30 |
| RB | Carlos Hyde RB | 22.00 |
| RB | Jordan Howard RB | 18.10 |
| WR | Donte Moncrief WR | 9.20 |
| WR | Willie Snead WR | 1.60 |
| TE | Travis Kelce TE | 5.70 |
| FLEX | Theo Riddick RB | 7.80 |
| FLEX | Cameron Brate TE | 16.60 |
| DST | Los Angeles Rams DST | 21.00 |
| Total | 116.3 | |
| Bench | ||
| Pos | Player | Points |
| BN | Matt Ryan QB | 11.90 |
| BN | Dak Prescott QB | 0.00 |
| BN | Ezekiel Elliott RB | 0.00 |
| BN | Amari Cooper WR | 5.30 |
| BN | Sammy Watkins WR | 1.60 |
| BN | Jack Doyle TE | 12.50 |
| BN | Minnesota Vikings DST | 15.00 |
| BN | Kendall Wright WR | 4.60 |
| BN | Robert Woods WR | 7.50 |
| BN | Michael Floyd WR | 1.00 |
| Bench | ||
| Pos | Player | Points |
| BN | David Johnson RB | 0.00 |
| BN | Derrick Henry RB | 21.00 |
| BN | Terrance West RB | 0.00 |
| BN | Devontae Booker RB | 10.00 |
| BN | Odell Beckham WR | 0.00 |
| BN | Jordan Matthews TE | 0.00 |
| BN | Tyler Lockett WR | 0.00 |
| BN | Philadelphia Eagles DST | 8.00 |
| BN | DeAngelo Henderson RB | 0.00 |
| BN | Jay Cutler QB | 11.90 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Tom Brady QB | 16.20 | 100% |
| RB | Melvin Gordon RB | 31.50 | 100% |
| RB | Tevin Coleman RB | 10.10 | |
| WR | Rishard Matthews WR | 8.90 | 68.9% |
| WR | Robert Woods WR | 7.50 | |
| TE | Jack Doyle TE | 12.50 | 57.6% |
| FLEX | Kyle Rudolph TE | 7.20 | 47.4% |
| FLEX | James White RB | 6.50 | |
| DST | Minnesota Vikings DST | 15.00 | 46.7% |
| Total | 115.4 | 77.8% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Philip Rivers QB | 14.30 | 100% |
| RB | Carlos Hyde RB | 22.00 | 93.3% |
| RB | Derrick Henry RB | 21.00 | |
| WR | Donte Moncrief WR | 9.20 | 100% |
| WR | Willie Snead WR | 1.60 | |
| TE | Cameron Brate TE | 16.60 | 34.3% |
| FLEX | Jordan Howard RB | 18.10 | 86.8% |
| FLEX | Devontae Booker RB | 10.00 | |
| DST | Los Angeles Rams DST | 21.00 | 100% |
| Total | 133.8 | 86.9% | |