| Starters | ||
| Pos | Player | Points |
| QB | Kyler Murray QB | 9.96 |
| RB | Kenyan Drake RB | 8.20 |
| RB | Dalvin Cook RB | 14.50 |
| WR | Allen Robinson WR | 19.30 |
| WR | Mike Evans WR | 12.60 |
| TE | Hunter Henry TE | 10.90 |
| FLEX | Randall Cobb WR | 5.30 |
| FLEX | Auden Tate WR | 2.10 |
| DST | New England Patriots DST | 7.00 |
| Total | 89.86 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jimmy Garoppolo QB | 28.06 |
| RB | Duke Johnson RB | 7.50 |
| RB | Kareem Hunt RB | 13.80 |
| WR | Tyler Lockett WR | 6.30 |
| WR | Michael Thomas WR | 24.90 |
| TE | Darren Waller TE | 8.20 |
| FLEX | DeVante Parker WR | 3.80 |
| FLEX | Marlon Mack RB | 9.80 |
| DST | Indianapolis Colts DST | 6.00 |
| Total | 108.36 | |
| Bench | ||
| Pos | Player | Points |
| BN | Peyton Barber RB | 6.30 |
| BN | Tom Brady QB | 10.76 |
| BN | Dion Lewis RB | 3.60 |
| BN | Frank Gore RB | 0.60 |
| BN | Adrian Peterson RB | 13.60 |
| BN | David Njoku TE | 0.90 |
| BN | Matt Breida RB | 6.30 |
| BN | Royce Freeman RB | 10.20 |
| BN | Hayden Hurst TE | 14.80 |
| BN | Marquez Valdes-Scantling WR | 0.00 |
| BN | NKeal Harry TE | 1.70 |
| Bench | ||
| Pos | Player | Points |
| BN | Jordan Howard RB | 0.00 |
| BN | Sammy Watkins WR | 7.00 |
| BN | Jacoby Brissett QB | 22.64 |
| BN | Corey Davis WR | 4.40 |
| BN | Tennessee Titans DST | 9.00 |
| BN | Raheem Mostert RB | 23.90 |
| BN | Nyheim Hines RB | 4.20 |
| BN | Noah Fant TE | 19.30 |
| BN | Damien Harris RB | 0.00 |
| BN | Preston Williams WR | 0.00 |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Tom Brady QB | 10.76 | 92.6% |
| RB | Dalvin Cook RB | 14.50 | 80.8% |
| RB | Adrian Peterson RB | 13.60 | |
| WR | Allen Robinson WR | 19.30 | 100% |
| WR | Mike Evans WR | 12.60 | |
| TE | Hayden Hurst TE | 14.80 | 73.6% |
| FLEX | Hunter Henry TE | 10.90 | 35.1% |
| FLEX | Royce Freeman RB | 10.20 | |
| DST | New England Patriots DST | 7.00 | 100% |
| Total | 113.66 | 79.1% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 28.06 | 100% |
| RB | Raheem Mostert RB | 23.90 | 56.5% |
| RB | Kareem Hunt RB | 13.80 | |
| WR | Michael Thomas WR | 24.90 | 96.9% |
| WR | Keke Coutee WR | 7.30 | |
| TE | Noah Fant TE | 19.30 | 42.5% |
| FLEX | Marlon Mack RB | 9.80 | 75.6% |
| FLEX | Darren Waller TE | 8.20 | |
| DST | Tennessee Titans DST | 9.00 | 66.7% |
| Total | 144.26 | 75.1% | |