| Starters | ||
| Pos | Player | Points |
| QB | Jameis Winston QB | 32.70 |
| RB | Aaron Jones RB | 17.10 |
| RB | Christian McCaffrey RB | 33.50 |
| WR | Davante Adams WR | 19.80 |
| WR | Robby Anderson WR | 10.60 |
| TE | Zach Ertz TE | 14.60 |
| FLEX | Jack Doyle TE | 3.10 |
| FLEX | Phillip Lindsay RB | 3.20 |
| DST | Pittsburgh Steelers DST | 6.00 |
| Total | 140.6 | |
| Starters | ||
| Pos | Player | Points |
| QB | Jimmy Garoppolo QB | 12.60 |
| RB | Marlon Mack RB | 1.90 |
| RB | Kareem Hunt RB | 11.60 |
| WR | Tyler Lockett WR | 22.00 |
| WR | Michael Thomas WR | 24.80 |
| TE | Darren Waller TE | 16.20 |
| FLEX | DeVante Parker WR | 21.20 |
| FLEX | Raheem Mostert RB | 10.40 |
| DST | Tennessee Titans DST | 5.00 |
| Total | 125.7 | |
| Bench | ||
| Pos | Player | Points |
| BN | T.Y. Hilton WR | 4.50 |
| BN | David Johnson RB | 0.60 |
| BN | Jamison Crowder WR | 24.00 |
| BN | Seattle Seahawks DST | 7.00 |
| BN | Aaron Rodgers QB | 14.40 |
| BN | Brandin Cooks WR | 6.60 |
| BN | James Conner RB | 13.10 |
| BN | Josh Allen QB | 16.40 |
| BN | Bo Scarbrough RB | |
| BN | Benny Snell Jr. RB | 0.10 |
| Bench | ||
| Pos | Player | Points |
| BN | Jordan Howard RB | |
| BN | Sammy Watkins WR | 8.40 |
| BN | Duke Johnson RB | 3.30 |
| BN | Jacoby Brissett QB | 7.30 |
| BN | Indianapolis Colts DST | -1.00 |
| BN | Corey Davis WR | 7.20 |
| BN | Nyheim Hines RB | 2.20 |
| BN | Noah Fant TE | 6.60 |
| BN | Damien Harris RB | |
| BN | Preston Williams WR | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jameis Winston QB | 32.70 | 100% |
| RB | Christian McCaffrey RB | 33.50 | 100% |
| RB | Aaron Jones RB | 17.10 | |
| WR | Jamison Crowder WR | 24.00 | 69.4% |
| WR | Davante Adams WR | 19.80 | |
| TE | Zach Ertz TE | 14.60 | 100% |
| FLEX | James Conner RB | 13.10 | 26.6% |
| FLEX | Robby Anderson WR | 10.60 | |
| DST | Seattle Seahawks DST | 7.00 | 85.7% |
| Total | 172.4 | 81.6% | |
| Potential Lineup | |||
| Pos | Player | Points | Eff % |
| QB | Jimmy Garoppolo QB | 12.60 | 100% |
| RB | Kareem Hunt RB | 11.60 | 61.4% |
| RB | Raheem Mostert RB | 10.40 | |
| WR | Michael Thomas WR | 24.80 | 100% |
| WR | Tyler Lockett WR | 22.00 | |
| TE | Darren Waller TE | 16.20 | 100% |
| FLEX | DeVante Parker WR | 21.20 | 106.8% |
| FLEX | Sammy Watkins WR | 8.40 | |
| DST | Tennessee Titans DST | 5.00 | 100% |
| Total | 132.2 | 95.1% | |